Archive for Nancy Fliesler
Reversing the trend: Easing the mental health boarding crisis in emergency rooms
Anxiety, depression, and suicide attempts have been rising over the past decade, especially among teens, often landing them in emergency departments (EDs). Due to a nationwide shortage of beds in psychiatric treatment programs, virtually all pediatric hospitals are having to keep patients in the ED and on inpatient medical and surgical floors — sometimes for ... Read More about Reversing the trend: Easing the mental health boarding crisis in emergency rooms
Mitochondrial transfer restores heart muscle — but how?
Transferring mitochondria from a patient’s healthy skeletal muscle to damaged, ischemic heart tissue has been shown to restore heart muscle, increase energy production, and improve ventricular function. After pioneering preclinical work by James McCully, PhD, at Boston Children’s Hospital about a decade ago, cardiac surgeons led by Sitaram Emani, MD, have been testing it as ... Read More about Mitochondrial transfer restores heart muscle — but how?
Brain wiring predicted adolescents’ emotional health during COVID
The COVID-19 pandemic was emotionally devastating for many adolescents, disrupting their schooling and social/emotional development. Drawing on national data, a large study finds that how adolescents’ brains were wired — before COVID-19 — predicted their stress, negative emotions, and overall mental health during the height of the pandemic, making them more vulnerable or more resilient. ... Read More about Brain wiring predicted adolescents’ emotional health during COVID
In a thriving gene therapy program, nursing leadership is the driving force
Gene therapy was made possible by decades of technological advances. But to execute gene therapy at scale? That would not be possible without the foresight, organization, and innovation of nursing leadership at Boston Children’s Hospital. The gene therapy implementation framework they have built has become a gold standard for the field. Founded in 2010, the ... Read More about In a thriving gene therapy program, nursing leadership is the driving force
Mending injured hearts: Lessons from newborns?
When the heart is injured, as in a myocardial infarction, the damaged heart muscle cannot regenerate — instead, scar tissue forms. Cardiomyocytes, the heart muscle cells that generate contractile force, are lost for good. Yet, in mouse models, the hearts of newborns regenerate readily after injury. How are newborn hearts able to recover? What are ... Read More about Mending injured hearts: Lessons from newborns?
Medical care for youth with neurodevelopmental disabilities: A call for change
According to national data, one in six children has a neurodevelopmental disability (NDD) such as autism, intellectual disability, or ADHD. Their medical care is often inadequate, sometimes leaving conditions untreated and neglecting preventive care — with poorer outcomes as the result. Clinicians may not take time to communicate with children, teens, and young adults with ... Read More about Medical care for youth with neurodevelopmental disabilities: A call for change
Building better antibodies, curbing autoimmunity: New insights on B cells
When we’re vaccinated or exposed to an infection, our B cells spring into action, churning out antibodies that are increasingly potent, specific, and protective. This happens through an iterative process known as affinity maturation. Two labs at Boston Children’s Hospital have come up with different ways to enhance affinity maturation and help B cells make ... Read More about Building better antibodies, curbing autoimmunity: New insights on B cells
A journey through the intestine during colitis, cell by cell
Inflammatory bowel disease (IBD), causing devastating abdominal pain, persistent diarrhea, and rectal bleeding, is hard to control with current treatments. Children often experience malnutrition and impaired growth. To get a better handle on IBD, researchers at Boston Children’s Hospital and Brigham and Women’s Hospital decided to eavesdrop on happenings in the colon. In the first ... Read More about A journey through the intestine during colitis, cell by cell
Exploring brain operations: Making decisions, snapping to attention, and forming memories
How do our brains snap to attention and orient us to the outside world — like when we’re sound asleep and the smoke alarm goes off? And when different choices confront us, how does our brain make decisions? Two groups of researchers at Boston Children’s explored these all-important brain operations. The first study, published February ... Read More about Exploring brain operations: Making decisions, snapping to attention, and forming memories
In the genetics of congenital heart disease, noncoding DNA fills in some blanks
Researchers have been chipping away at the genetic causes of congenital heart disease (CHD) for a couple of decades. About 45 percent of cases of CHD have an identifiable cause, including chromosomal abnormalities, genetic variants affecting protein-coding genes, and environmental factors. What about the rest of the cases of CHD? Noncoding DNA elements have long ... Read More about In the genetics of congenital heart disease, noncoding DNA fills in some blanks