Archive for car t-cell therapy
Making ready-made CAR T cells for cancer immunotherapy
In CAR T-cell immunotherapy, T cells from a patient’s own blood are engineered to carry so-called chimeric antigen receptors (CAR) that enable the T cells to attack and kill tumor cells. While CAR-T therapy is a powerful approach for certain leukemias and lymphomas, it’s not available for many patients who need it. It can be ... Read More
CAR T-cell therapy helps young hockey fan ice pediatric leukemia
Due to COVID-19, Ava Girolimetti wasn’t sure if she would be starting middle school this year in a classroom, on a computer screen, or a combination of both. But thanks to CAR T-cell therapy for acute lymphoblastic leukemia (ALL), she knew she would be there cancer-free. The rising sixth grader can make this claim as ... Read More
‘Nanobodies’ from alpacas could help bring CAR T-cell therapy to solid tumors
In 1989, two undergraduate students at the Free University of Brussels were asked to test frozen blood serum from camels, and stumbled on a previously unknown kind of antibody. It was a miniaturized version of a human antibody, made up only of two heavy protein chains, rather than two light and two heavy chains. As ... Read More
Cole: Having a ball after CAR T-cell therapy
After undergoing a promising new treatment for acute lymphoblastic leukemia (ALL), Cole Malone is back to doing what he loves: playing on a flag football team with his twin brother, Michael. Cole and Michael, 14, already know plenty about teamwork. Michael served as a perfect-match donor when Cole had a stem cell transplant at Dana-Farber/Boston Children’s Cancer and Blood ... Read More