Archive for cardiac research
Finding a way to help newborns who can’t immediately have heart treatment
Newborns with complex congenital heart defects (CHD) and pulmonary overcirculation often need treatment as soon as possible. Unfortunately, some of these children are not in good enough health to withstand surgery. To address this challenge, Boston Children’s heart specialists leaned into technological innovation, their experience, and a perseverance that would ultimately confirm their belief that even the ... Read More
Experience and innovation create a safer type of heart surgery
The Eureka moment came the day before heart surgery. Easton Schlein wasn’t an ideal candidate for a full-scale surgical repair of an underdeveloped left ventricle. But his cardiac surgeons weren’t satisfied that they instead had to use the Fontan procedure, the only other option for that condition, but one associated with long-term liver complications. Reviewing ... Read More
A heart valve that grows along with a child could reduce invasive surgeries
Clinical trials have started for the first prosthetic pulmonary valve replacement that is specifically designed for pediatric patients and can expand over time inside a child’s anatomy. Instead of having invasive replacement surgeries every few years, as is the practice now, a child can have the valve fitted to their individual body size and, if ... Read More
A new view of heart health: Mutations accumulate in the heart starting in childhood
Why do so many people get heart disease when they get older? We know that factors like high blood pressure or high cholesterol contribute to heart disease risk, but they don’t explain all cases. A first-of-its-kind study from Boston Children’s Hospital offers a new lens on heart health. It shows that the cells of our ... Read More
A new lens on cardiac surgery could help prevent arrhythmia
Sometimes, a change in perspective can lead to a medical breakthrough. A type of microscopy typically used to detect cancer and other diseases has been adapted to reveal the location of unseen conduction tissue around the heart. The Boston Children’s clinician behind this innovation now aims to prove the safety and effectiveness of fiber-optic confocal ... Read More
Getting to the heart of heart muscle function
Every heart muscle cell, or cardiomyocyte, is studded with tiny, intricate structures called dyads. The dyads are like orchestra conductors: They coordinate incoming electrical signals with release of calcium in the muscle, triggering contraction. When dyads work properly, the different segments of heart muscle contract in unison; when they don’t, heartbeats may be too weak ... Read More
“Seeing” the unseen: A way to pinpoint elusive cardiac conduction tissue
When patients with congenital heart issues have an operation, surgeons have to proceed with an “eye of faith” as they work around conduction tissue — a network of cells and electrical signals that control the beating of a heart. Not visible to the naked eye, conduction systems vary person to person, but they’re particularly difficult ... Read More
Wanting to give back, four heart patients now work as heart pros
They belong to a unique group. As children, they needed surgery to repair congenital heart conditions. Rather than being afraid, they instead were curious about the science behind their treatment. What they learned motivated them to discover more and ultimately pursue careers in medicine. Now healthy adults and working for the Benderson Family Heart Center at Boston ... Read More
COVID-19 vaccination in 12- to 18-year-olds: What does the science say?
With a third “booster” dose of the Pfizer/BioNTech vaccine now authorized for children age 12 and older, you may be wondering about the safety and effectiveness of COVID-19 vaccination in teens. With months of experience — and recent research — to draw from, we now have more answers. Several recent studies led or co-led by ... Read More
Bringing the Ozaki procedure to the world to repair children’s aortic valves
Children with aortic stenosis or regurgitation often need surgery to reconstruct or replace the aortic valve. However, existing bioprosthetics can fail over time, and mechanical leaflets and valves require lifelong anticoagulant therapy. Christopher Baird, MD, director of the Congenital Heart Valve Program at Boston Children’s Hospital, saw a promising alternative emerge in adult cardiac surgery: aortic ... Read More