Archive for Nancy Fliesler
Suicide prevention in teens: Can we intervene through primary care?
The past year has seen a disturbing rise in suicidal thoughts and attempts among adolescents, with a spike of suicidal teens going to emergency departments (EDs). This adds to a growing trend: From 2007 to 2016, ED visits for deliberate self-harm more than quadrupled nationwide among children age 5 to 17. In a recent review ... Read More about Suicide prevention in teens: Can we intervene through primary care?
When worlds collide: Glycosylated RNAs upend cell biology as we know it
Cells in our body bristle with sugars known as glycans that other cells can recognize via specialized receptors. Glycans attach to and modify proteins and fats, thereby influencing how proteins fold, how cues are trafficked between cells, and other cell-to-cell interactions. As just one example of glycans’ importance, our blood types (A, B, O) depend ... Read More about When worlds collide: Glycosylated RNAs upend cell biology as we know it
After a long journey and a father’s gift, surviving Wilms tumor
Eleanor (Nora) Franks was a happy, healthy toddler who loved playing with her twin brother Evan. But soon after she turned 3, she began having problems with her digestion. Eventually, her local hospital found a large mass in her kidney and diagnosed her with Wilms tumor, a rare kidney cancer. “She had to go almost ... Read More about After a long journey and a father’s gift, surviving Wilms tumor
Eating disorders in the time of COVID: Advice for parents
As the COVID-19 pandemic has worn on, it has led to a secondary epidemic of eating disorders among children and teens. In January, the National Eating Disorders Association reported a spike of activity on its help lines. And treatment programs are having trouble keeping up with the requests. “We have seen a huge increase in ... Read More about Eating disorders in the time of COVID: Advice for parents
Can we explain sudden infant deaths? It’s complicated.
Since the early 1990s, “Back to Sleep” campaigns have urged parents to place infants to bed on their backs to prevent suffocation and sudden infant death syndrome (SIDS). The results were clear: from 1992 to 1996, SIDS fell by more than half. But since then, rates of what is now called sudden unexpected infant death (SUID) ... Read More about Can we explain sudden infant deaths? It’s complicated.
Can we prevent leukemia in patients with Shwachman-Diamond syndrome?
Anna Nazarenko doesn’t see herself as sick. The strong-willed, spunky 6-year-old loves to dance and ski, and spent much of April Fool’s day pranking her parents. Aside from the enzymes she takes to help digest her food, you wouldn’t know that she has Shwachman-Diamond syndrome (SDS). The rare, inherited type of bone marrow failure has ... Read More about Can we prevent leukemia in patients with Shwachman-Diamond syndrome?
Newborn genetic screening for pediatric cancer risk could save lives
Numerous genetic mutations increase children’s risk for various cancers. When they are detected early, cancers can potentially be caught at an early, more treatable stage — or avoided entirely. Could adding such “cancer predisposition” genes to routine newborn “heel-stick” screening save lives? Lisa Diller, MD, chief medical officer at the Dana-Farber/Boston Children’s Cancer and Blood ... Read More about Newborn genetic screening for pediatric cancer risk could save lives
Boston Children’s Simulator Program steps up during COVID-19
In the early days of the COVID-19 pandemic, hospitals scrambled to adapt and prepare. Amid the chaos, the Boston Children’s Hospital Simulator Program, SIMPeds, sprang into action. SIMPeds is a world leader in running live simulations of care scenarios, allowing health care providers to rehearse tough or unanticipated situations in advance. Its SIMEngineering division is ... Read More about Boston Children’s Simulator Program steps up during COVID-19
Sturdier spikes may explain SARS-CoV-2 variants’ faster spread
The fast-spreading U.K., South Africa, and Brazil variants are raising concerns and questions about whether current COVID-19 vaccines will protect against them. A structural biology study led by Bing Chen, PhD, at Boston Children’s Hospital now reveals how the D614G mutation — carried by all three variants — makes SARS-CoV-2 spread faster. Key takeaways: The main ... Read More about Sturdier spikes may explain SARS-CoV-2 variants’ faster spread
Looking for cancer’s Achilles heel: The Pediatric Cancer Dependency Map
Thanks to developments in precision medicine, some adult cancers are now treated with designer drugs that target the genetic mutations that caused them. But most children with cancer have not reaped the same benefits. Unlike adult cancers, childhood cancers carry few genetic mutations. And the mutations these tumors do have are typically harder to make ... Read More about Looking for cancer’s Achilles heel: The Pediatric Cancer Dependency Map