Archive for Nancy Fliesler
Soft stents, hardened in place by UV light, allow a snug, custom fit
Airway stents are often used when the trachea and bronchi need to be buttressed, as in children and adults with tracheobronchomalacia whose airways become “floppy” and collapse during normal breathing. This condition can occur in conjunction with congenital cardiac anomalies in which the major heart vessels compress the trachea, and with severe, recurrent bronchitis. But ... Read More about Soft stents, hardened in place by UV light, allow a snug, custom fit
Avoiding a lifetime of injections: Can gene editing cure severe congenital neutropenia?
Fionn Mulrooney, a cheerful 11-month-old, in Plymouth, Massachusetts, has no idea he has a life-threatening genetic disease. Nor does he seem fazed by the daily subcutaneous injections his parents have learned how to give him. And little does he know that cells from his bone marrow are helping scientists develop an innovative gene-editing approach that ... Read More about Avoiding a lifetime of injections: Can gene editing cure severe congenital neutropenia?
If another pandemic hits, our online ‘footprints’ may help the experts
When the new coronavirus hit early last year, little was known about it. As people started coming to the emergency room, doctors scrambled to understand COVID-19 and its trajectory of symptoms. Testing was limited, and only over a period of months did the full fury of the new virus make itself known. Community after community ... Read More about If another pandemic hits, our online ‘footprints’ may help the experts
Looking for a coronavirus vaccine near you? VaccineFinder may have answers
Soon, any American eligible to receive a COVID-19 vaccine will be able to search VaccineFinder, an easy-to-use website hosted and run by Boston Children’s Hospital with funding from the Centers for Disease Control and Prevention (CDC). The site went live last week in Alaska, Tennessee, Indiana and Iowa, and will be extended to other states as vaccine distribution ramps ... Read More about Looking for a coronavirus vaccine near you? VaccineFinder may have answers
Is it MIS-C or severe COVID-19? An update on multisystem inflammatory syndrome in children
In May 2020, multisystem inflammatory syndrome in children (MIS-C) was formally recognized as a post-infectious syndrome in children exposed to the SARS-CoV-2 coronavirus. In today’s JAMA, a study led by Boston Children’s Hospital refines the medical understanding of MIS-C. Its findings help distinguish this rare condition from severe, acute COVID-19 in children, with which it ... Read More about Is it MIS-C or severe COVID-19? An update on multisystem inflammatory syndrome in children
How do patients with cystic fibrosis respond to COVID-19? An ‘airway in a dish’ may give answers
So far, based on clinical data, patients with cystic fibrosis (CF) don’t appear to be especially susceptible to COVID-19. And when they do get infected, they don’t seem to get sicker. But Ruobing (Ruby) Wang, MD, who cares for patients with CF in the Division of Pulmonary Medicine at Boston Children’s Hospital, thinks there is ... Read More about How do patients with cystic fibrosis respond to COVID-19? An ‘airway in a dish’ may give answers
Getting COVID-19 vaccines to medically fragile children
As COVID-19 vaccines slowly roll out, should children who need complex care or have serious medical conditions be vaccinated? We asked experts around Boston Children’s Hospital, and their resounding answer is: Yes, if they are age 16 or older. Boston Children’s is actively planning to make vaccination happen for as many patients as possible, as ... Read More about Getting COVID-19 vaccines to medically fragile children
Pharmacogenomics: Nearly 30 percent of children could benefit, study finds
Medications aren’t one-size-fits-all. Genetic differences can affect how patients metabolize drugs, and can sometimes make a beneficial drug ineffective or even toxic. In one infamous case, a 2-year-old boy in Canada died from a codeine dose he received after surgery. A genetic difference caused him to metabolize codeine so quickly that toxic levels of morphine ... Read More about Pharmacogenomics: Nearly 30 percent of children could benefit, study finds
‘Mosaic’ gene mutations could explain some cases of autism
The causes of autism remain mysterious. Scientists have linked autism spectrum disorder to a long list of genes, but most children with autism have no known explanation. Two new studies add to the picture, implicating mutations that affect only a fraction of a child’s cells. Called mosaic mutations, they open a new avenue for research ... Read More about ‘Mosaic’ gene mutations could explain some cases of autism
Arthritis drug reduces rates of acute graft-vs-host disease after bone marrow transplant
The immune-suppressing drug abatacept, currently used for rheumatoid arthritis, could make bone marrow transplant safer, report researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. The phase 2 randomized, multi-center clinical trial, the largest to date, appears in the Journal of Clinical Oncology. Abatacept (brand name ORENCIA) reduced rates of severe, acute graft-versus-host disease ... Read More about Arthritis drug reduces rates of acute graft-vs-host disease after bone marrow transplant