Mobile ‘location’ data could help guide COVID-19 social distancing measures
How well are quarantines and social distancing working to slow the COVID-19 pandemic? When is it safe for us to return to school or work? The answers could lie, in part, in the “location” data that companies like Google collect from us every day. Last week, a group of epidemiologists, public health experts, and data ... Read More about Mobile ‘location’ data could help guide COVID-19 social distancing measures
COVID-19 and children: Understanding the science
As information on COVID-19 pours in from all kinds of sources, not all of them reliable, we wanted to bring you the facts about how children and teens appear to be responding to the infection. In recent weeks, several highly respected medical journals have published studies and commentaries based on observations in children and teens ... Read More about COVID-19 and children: Understanding the science
Crowdsourcing the COVID-19 pandemic in real time
News about the global COVID-19 pandemic changes virtually minute by minute. Beyond staying home, handwashing, and covering your cough, you may wonder what you can do to help. A new website developed by the HealthMap team at Boston Children’s Hospital, COVID Near You, offers one way. Taking a moment to share your health status on ... Read More about Crowdsourcing the COVID-19 pandemic in real time
Gasdermin E: A new approach to cancer immunotherapy
Tumors have figured out various ways to prevent the immune system from attacking them. Medicine, for its part, has fought back with cancer immunotherapy. The major approach uses checkpoint inhibitors, drugs that help the immune system recognize cancer cells as foreign. Another method, CAR T-cell therapy, directly engineers peoples’ T cells to efficiently recognize cancer ... Read More about Gasdermin E: A new approach to cancer immunotherapy
Designing a coronavirus vaccine for next year – and the years beyond
As the number of coronavirus infections swell daily across the globe, strategies for developing a safe and effective vaccine are rapidly moving forward. In response to this public health crisis, the Precision Vaccines Program (PVP) at Boston Children’s Hospital is on the front lines of developing a coronavirus vaccine targeted especially toward older populations, those ... Read More about Designing a coronavirus vaccine for next year – and the years beyond
Gene therapy reverses heart failure in mouse model of Barth syndrome
Barth syndrome is a rare metabolic disease caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and impairs overall growth. Because Barth syndrome is X-linked, it almost always occurs in boys. There is no cure or specific treatment. ... Read More about Gene therapy reverses heart failure in mouse model of Barth syndrome
Mouse model could lead to new treatments for endometriosis pain
There are few effective long-term treatments for endometriosis; even fewer options for relieving the often severe pain associated with the condition, which involves tissue overgrowth outside of the uterus. As a first step toward identifying new pain treatments, researchers in the laboratory of Michael Rogers, PhD, in the Vascular Biology Program at Boston Children’s Hospital, ... Read More about Mouse model could lead to new treatments for endometriosis pain
Mouse/human model provides new way to study neuroblastoma
Neuroblastoma is a rare childhood cancer affecting about 800 children each year in the United States. Because of its unusual behavior — tumors in infants often disappear spontaneously without treatment while it can be aggressive and fatal in toddlers — studying the disease has been complicated. That may change with a new research tool: a ... Read More about Mouse/human model provides new way to study neuroblastoma
S1P and its receptor: New approaches to cancer?
In 1998, when Timothy Hla, PhD, and his colleagues identified and cloned the receptor for sphingosine-1-phosphate (S1P), it generated a lot of excitement. S1P, a lipid originally discovered in the 1960s, was known to play various roles in the body and in disease. But it wasn’t thought that lipids could have receptors, and it wasn’t ... Read More about S1P and its receptor: New approaches to cancer?
Long-term hemophilia treatment could lie in patients’ own cells
Children (and adults) with hemophilia are slow to form blood clots, so are at constant risk for uncontrolled bleeding. Even when the skin isn’t broken, a fall or a simple toe stub can become a serious medical issue: internal bleeding cause permanent damage to muscles and joints. While regularly replacing the missing or malfunctioning clotting ... Read More about Long-term hemophilia treatment could lie in patients’ own cells