Piecing together the preterm infant microbiome
The human microbiome — the collection of microbes living in the gut — is now recognized as an important contributor to health and disease. The environment, the host, and microbe-microbe interactions are all likely to shape the microbiome’s dynamics, but the unique roles of each are not well understood. Now, a Boston Children’s Hospital infectious ... Read More about Piecing together the preterm infant microbiome
Can we prevent leukemia in patients with Shwachman-Diamond syndrome?
Anna Nazarenko doesn’t see herself as sick. The strong-willed, spunky 6-year-old loves to dance and ski, and spent much of April Fool’s day pranking her parents. Aside from the enzymes she takes to help digest her food, you wouldn’t know that she has Shwachman-Diamond syndrome (SDS). The rare, inherited type of bone marrow failure has ... Read More about Can we prevent leukemia in patients with Shwachman-Diamond syndrome?
Diversifying therapeutic antibodies: From one, come many with potential different uses
A new method for producing antibodies against disease could result in a wider variety of drugs for infectious diseases, immune disease, and even cancer. The immune system naturally produces enormous varieties of antibodies to fight diseases. Therapeutic antibodies — antibodies created against specific therapeutic targets — have been used for decades to either rev up ... Read More about Diversifying therapeutic antibodies: From one, come many with potential different uses
Game-changing surgical procedure results in zero-percent TEF re-recurrence rate
A tracheaesophageal fistula (TEF) is a congenital defect in which an abnormal connection forms between a child’s esophagus and trachea. It often occurs with esophageal atresia. Even after surgical repair, TEFs recur in about 10 to 15 percent of infants and children. They rarely close spontaneously and typically require surgical or endoscopic intervention. Key takeaways: ... Read More about Game-changing surgical procedure results in zero-percent TEF re-recurrence rate
Sturdier spikes may explain SARS-CoV-2 variants’ faster spread
The fast-spreading U.K., South Africa, and Brazil variants are raising concerns and questions about whether current COVID-19 vaccines will protect against them. A structural biology study led by Bing Chen, PhD, at Boston Children’s Hospital now reveals how the D614G mutation — carried by all three variants — makes SARS-CoV-2 spread faster. Key takeaways: The main ... Read More about Sturdier spikes may explain SARS-CoV-2 variants’ faster spread
Looking for cancer’s Achilles heel: The Pediatric Cancer Dependency Map
Thanks to developments in precision medicine, some adult cancers are now treated with designer drugs that target the genetic mutations that caused them. But most children with cancer have not reaped the same benefits. Unlike adult cancers, childhood cancers carry few genetic mutations. And the mutations these tumors do have are typically harder to make ... Read More about Looking for cancer’s Achilles heel: The Pediatric Cancer Dependency Map
Soft stents, hardened in place by UV light, allow a snug, custom fit
Airway stents are often used when the trachea and bronchi need to be buttressed, as in children and adults with tracheobronchomalacia whose airways become “floppy” and collapse during normal breathing. This condition can occur in conjunction with congenital cardiac anomalies in which the major heart vessels compress the trachea, and with severe, recurrent bronchitis. But ... Read More about Soft stents, hardened in place by UV light, allow a snug, custom fit
Laparoscopic approach to cloacal malformation repair found safe in eligible patients
A minimally invasive surgical approach called laparoscopic rectal mobilization and urogenital separation appears to be a safe alternative to open surgery in eligible patients with cloacal malformations. That’s the conclusion of a recent study by the team in the Colorectal and Pelvic Malformation Center at Boston Children’s Hospital. A minimally invasive approach to urogenital separation ... Read More about Laparoscopic approach to cloacal malformation repair found safe in eligible patients
Neurological involvement common in kids and teens with acute COVID-19 and MIS-C
In the largest study of its kind, researchers from Boston Children’s Hospital found neurological involvement in 22 percent of children and adolescents hospitalized with acute COVID-19 or multisystem inflammatory syndrome in children (MIS-C). These symptoms included fatigue, headache, confusion, difficulty walking or crawling, or loss of taste and smell. However, 1 in 8 children with ... Read More about Neurological involvement common in kids and teens with acute COVID-19 and MIS-C
If another pandemic hits, our online ‘footprints’ may help the experts
When the new coronavirus hit early last year, little was known about it. As people started coming to the emergency room, doctors scrambled to understand COVID-19 and its trajectory of symptoms. Testing was limited, and only over a period of months did the full fury of the new virus make itself known. Community after community ... Read More about If another pandemic hits, our online ‘footprints’ may help the experts