Research
illustration of crawling baby emphasizing brain and globus pallidus within the brain

Tuber locations associated with infantile spasms map to a common brain network

About half of all babies with tuberous sclerosis complex (TSC) develop infantile spasms, a type of epilepsy that can have serious long-term neurologic consequences. Infantile spasms occur more often in children who have more brain tubers — groups of cells that do not divide into normal neurons and brain cells — but we haven’t known ... Read More
Health and Parenting
mother comforting daughter while sitting on a bed

Talking with your child about loss and death

The death toll from COVID-19 has recently surpassed more than 400,000 in the United States and continues to climb. This means that thousands of children have lost someone close to them — a grandparent, an aunt or uncle, a family friend, or even a parent. Some children have lost more than one loved one. Talking ... Read More
Research
an illustration of a hand and arm with a wristband to detect seizures

Predicting pediatric seizures with a wristband: Study shows what’s possible

The ability to track seizures has a number of potential benefits: It could allow physicians to better determine optimal dosing and timing of medication, as well as enable timely interventions to help prevent impending seizures. Traditionally, electroencephalography (EEG) and electrocorticography have been used to evaluate and forecast seizures. However, more compact, portable approaches — such ... Read More
Clinical Care
pharmacogenomics

Pharmacogenomics: Nearly 30 percent of children could benefit, study finds

Medications aren’t one-size-fits-all. Genetic differences can affect how patients metabolize drugs, and can sometimes make a beneficial drug ineffective or even toxic. In one infamous case, a 2-year-old boy in Canada died from a codeine dose he received after surgery. A genetic difference caused him to metabolize codeine so quickly that toxic levels of morphine ... Read More
Clinical Care
Drs. Fishman and Bae, two of the healthcare leaders who help ensure surgical procedures remain safe during COVID-19.

COVID-19 and surgery: Lessons in safety

When Massachusetts recorded its first COVID-19-positive test result in early March 2020, health officials knew little about the virus. They didn’t know, for instance, how it was transmitted or how to protect patients and clinicians during surgical procedures. In the weeks that followed, Boston Children’s Hospital made several difficult but necessary decisions. We cancelled elective ... Read More