Archive for Nancy Fliesler
Platelet profiles could enhance care for bleeding disorders, cardiovascular disease, cancer
The trillion-odd platelets in our blood are best known for controlling bleeding, helping clots form when we sustain an injury. But platelets can also go rogue. They contribute to clotting in cardiovascular disease and diabetes, leading to strokes and heart attacks, and can be hijacked by cancers to help them spread. Key takeaways A new ... Read More about Platelet profiles could enhance care for bleeding disorders, cardiovascular disease, cancer
Lung ‘organoids’ capture early-stage lung cancer; could help test treatments
Lung cancer, the leading cancer killer in the U.S., is often missed in its earlier stages. And while recent imaging advances offer earlier detection, early-stage lung cancers still have no targeted treatments. Key takeaways Mini “organoids” made from lung cells offer a rapid platform for tracking early-stage lung cancers and for testing possible treatments. RNA ... Read More about Lung ‘organoids’ capture early-stage lung cancer; could help test treatments
Gene therapy’s future may be all about the bases
Gene therapy offers the possibility of a cure for many genetic disorders, especially those involving a single gene. The first kind of gene therapy used a virus to carry a corrected copy of the gene into people’s cells. When the early viral vectors used in the 1990s were found to have off-target effects, sometimes even ... Read More about Gene therapy’s future may be all about the bases
Trial tests dornase alfa, a cystic fibrosis drug, for severe COVID pneumonia
Boston Children’s Hospital and Brigham and Women’s Hospital will soon begin testing an existing drug, dornase alfa, in patients with severe COVID-19 pneumonia and respiratory failure. The randomized, controlled clinical trial aims to enroll 60 adults and children over age 3 who require mechanical ventilation. Key takeaways:· A randomized trial is testing whether a cystic ... Read More about Trial tests dornase alfa, a cystic fibrosis drug, for severe COVID pneumonia
A master regulator of kidney health?
End-stage kidney disease often begins with injury to podocytes. These highly specialized cells are a critical part of the glomeruli, clusters of capillaries that serve as the filtration units in our kidneys’ tightly-packed nephrons. As their name suggests, podocytes extend tiny foot processes to intermingle with the capillaries and filter the blood, maintaining the proper ... Read More about A master regulator of kidney health?
Capturing SARS-CoV-2’s shape-shifting spike protein
The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic. The spikes bind to human cells via the ACE2 receptor and then dramatically change shape. They jack-knife, folding in on themselves to fuse their own membrane with the membrane of our cells. And that opens ... Read More about Capturing SARS-CoV-2’s shape-shifting spike protein
Monitoring for breast cancer after childhood chest radiation: When and how?
Chest radiation is used to treat children with Hodgkin and non-Hodgkin lymphoma as well as lung metastases in various solid tumors. But radiation itself is a potential cancer risk. That includes an increased risk for breast cancer later in life. Girls receiving chest radiation for childhood cancer face a breast cancer risk as high as ... Read More about Monitoring for breast cancer after childhood chest radiation: When and how?
Internet searches provide real-time estimate of Lyme disease risk
Lyme disease season is well underway. How much of a risk do we face for this tick-borne illness? A new method dubbed Lymelight, developed by researchers at Boston Children’s Hospital and Google, can accurately estimate Lyme disease risk in real time, down to the county level. Historically, estimates of Lyme disease have been based on ... Read More about Internet searches provide real-time estimate of Lyme disease risk
More details on MIS-C, the post-COVID multi-system inflammatory syndrome in children
Boston Children’s Hospital and collaborators launched the national Overcoming COVID-19 study in April to track children, teens, and young adults hospitalized with COVID-19 across the U.S. In yesterday’s New England Journal of Medicine, investigators provides a fuller picture of the still-mysterious, life-threatening multi-system inflammatory syndrome in children (MIS-C). Key takeaways· The largest case series of ... Read More about More details on MIS-C, the post-COVID multi-system inflammatory syndrome in children
Boston Children’s Hospital leads national study on pediatric COVID-19 and MIS-C
Why are children largely spared from COVID-19 — and why do a few become extremely sick? To find out, Boston Children’s Hospital launched a national study in April to perform real-time surveillance at more than 35 U.S. children’s hospitals. In May, when multi-system inflammatory syndrome in children (MIS-C) began appearing, that still-mysterious condition was added ... Read More about Boston Children’s Hospital leads national study on pediatric COVID-19 and MIS-C