Archive for biomarkers
Could we intervene in Huntington’s disease before symptoms appear?
Huntington’s disease is the most common single-gene neurodegenerative disorder and is characterized by motor and cognitive deficits and psychiatric symptoms. Work led by Beth Stevens, PhD, and Dan Wilton, PhD, in the Department of Neurology at Boston Children’s Hospital, now shows that the disease process begins well before symptoms appear. That raises the possibility of ... Read More about Could we intervene in Huntington’s disease before symptoms appear?
Immune biomarkers predicted COVID-19 severity and could help in future pandemics
Why did some people fall critically ill from COVID-19 and others not? In May 2020, as COVID-19 swept the world, Boston Children’s Hospital helped launch a national, NIAID-funded study called IMPACC (IMmunoPhenotyping Assessment in a COVID-19 Cohort). Taking a “systems immunology” approach, the goal was to document the virus’s impact on the immune system in ... Read More about Immune biomarkers predicted COVID-19 severity and could help in future pandemics
Deep plasma proteomics: Back to the future
Blood plasma is collected from people routinely during clinical care and for research. It is potentially a rich source of protein biomarkers for diagnostic and prognostic purposes, for measuring response to treatment, and for revealing disease biology. Yet identifying such biomarkers in plasma with proteomics, our best available tool, has been a challenge: Ninety-nine percent ... Read More about Deep plasma proteomics: Back to the future
Could concussion be monitored through urine samples?
Concussion can be frustratingly hard to diagnose and track. The injury doesn’t show up on routine brain scans, and there is no definitive diagnostic test. It’s usually diagnosed based on symptoms and, in athletes, comparison with baseline testing if it was done. But concussion symptoms are non-specific, unreliable, and easily influenced by emotions. “Athletes usually ... Read More about Could concussion be monitored through urine samples?
Preventing leukemia by preventing rogue blood cells from taking over
As we age, many of us acquire mutations that cause some of our blood stem cells to multiply faster than others, forming their own distinct populations or “clones.” This is known as clonal hematopoiesis. In some cases, a single clone originating from a single genetically altered or mutated stem cell can expand to comprise up ... Read More about Preventing leukemia by preventing rogue blood cells from taking over
Groundbreaking research identifies noninvasive biomarker for moyamoya in children
Moyamoya is a rare blood vessel condition that has an outsized impact on children, as it is responsible for about 6 percent of pediatric strokes in the United States. Surgical revascularization is the only treatment and is very effective. However, clinicians face challenges in identifying new or worsening disease before a disabling stroke occurs, predicting ... Read More about Groundbreaking research identifies noninvasive biomarker for moyamoya in children
Tau protein changes correlate with Alzheimer’s disease dementia stage
Research into Alzheimer’s disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients’ brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain. Key takeaways A pathological form of the tau protein contributes to the ... Read More about Tau protein changes correlate with Alzheimer’s disease dementia stage
Platelet profiles could enhance care for bleeding disorders, cardiovascular disease, cancer
The trillion-odd platelets in our blood are best known for controlling bleeding, helping clots form when we sustain an injury. But platelets can also go rogue. They contribute to clotting in cardiovascular disease and diabetes, leading to strokes and heart attacks, and can be hijacked by cancers to help them spread. Key takeaways A new ... Read More about Platelet profiles could enhance care for bleeding disorders, cardiovascular disease, cancer
Tracking an organism’s development, cell by cell
A new mouse model allows scientists to track every cell in the body — from the embryo stage until adulthood. The system is the first of its kind and should yield a greater understanding of development, aging, and disease. Scientists described it last week in the journal Cell. “The dream of many developmental biologists for ... Read More about Tracking an organism’s development, cell by cell
Making an IMPACC: Examining immune responses in people hospitalized with COVID-19
We know that the consequences of COVID-19 disease start by infection from a virus. But how does the body react to that viral invasion? To answer that question, Boston Children’s Hospital will play key roles in a nationwide study designed to learn how the immune systems of people hospitalized with COVID-19 respond to the disease ... Read More about Making an IMPACC: Examining immune responses in people hospitalized with COVID-19