The treatments and interventions used in medicine are often based on the results of clinical trials. But trials involving adults haven’t always represented the population as a whole, tending to recruit mostly white middle-class people. As a result, it’s not clear how well the findings apply to people of other racial and ethnic backgrounds. Do ... Read More about Clinical trials in children: Is there racial equity?
Despite the popularity of low-carbohydrate diets, health experts have pushed low-fat diets for the past 50 years, citing saturated fat as the main health risk. As a result, grocery shelves are stocked with low-fat and fat-free foods, many of which are high in processed carbs. Drs. David Ludwig and Cara Ebbeling, who co-direct the New ... Read More about Low-carb or low-fat? Study pinpoints better diet
Neonatal seizures can lead to serious consequences, including significant cognitive and motor disabilities, lifelong epilepsy, and death. They are often highly resistant to treatment, in part because seizures in newborns are fundamentally different from seizures in older children and adults. Yet they are treated in much the same way as older patients, with little change over the decades. Better treatment is ... Read More about A promising new antiseizure drug tailored to newborns
Children and adults of color have higher rates of asthma than white people, as well as more hospitalizations and deaths. There are many reasons for this disparity, including more exposure to allergens and pollutants and differences in asthma care. One difference, however, is genetic. A mutation that causes severe, hard-to-treat asthma, in the gene ILR4, ... Read More about Trial for severe asthma targets a mutation common in children of color
Until recently, babies and children with spinal muscular atrophy (SMA) lacked any type of treatment capable of stopping the neuromuscular disease from progressing. In SMA, damaged motor neurons in the spinal cord fail to correctly send messages to the muscle cells. As a result, infants and children with SMA may not be able to hold ... Read More about Risdiplam improves motor function in infants with spinal muscular atrophy
About 2.4 percent of preschool-age children have an attention-deficit/hyperactivity disorder (ADHD) diagnosis. For these children, behavioral interventions intended to redirect a child or otherwise replace negative behaviors with positive ones are the first line of treatment. But what if symptoms linger, or are so severe that they interfere with a child’s social, emotional, and educational ... Read More about ADHD drug class leads to fewer side effects in preschool children
Now that adults and older teens are receiving COVID-19 vaccines, some younger kids are wondering why they can’t get vaccinated too. While testing has begun in children 6 months to age 12, we aren’t ready to begin vaccinating most kids yet. But we do know the steps the companies are taking to be sure their ... Read More about COVID-19 vaccines for kids: What has to happen first
After a long, difficult year, the world had reason to celebrate in late 2020 when the U.S. Food and Drug Administration (FDA) authorized two COVID-19 vaccines for emergency use. Many more COVID-19 vaccines are in various stages of development. Several of these are in the final stage of clinical trials and could be submitted for ... Read More about What’s the difference between the COVID-19 vaccines?
In late November, the U.S. Food and Drug Administration (FDA) approved a repurposed cancer drug called lonafarnib to treat Hutchinson-Gilford progeria syndrome, better known as progeria — an ultra-rare incurable genetic disease associated with rapid aging. On average, children with progeria die before age 15, usually the result of rapidly accelerated atherosclerosis resulting in heart ... Read More about It’s personal: How the Boston Children’s progeria research community brought new life to an old drug
A pair of recent studies suggests that even among patients receiving advanced cancer care, poverty is a predictor of worse outcomes. The disturbing findings raise many questions that follow-up studies are now exploring. Key takeaways Poverty was associated with 3.7-fold higher mortality among children receiving targeted immunotherapy for high-risk neuroblastoma. Household poverty was associated with ... Read More about Poverty predicts worse cancer outcomes, even in children receiving top-tier care