Research

New stem cell pipeline makes more lifelike cell products

Researchers in many fields of science and medicine engineer different types of human cells for drug testing and other purposes. They often begin with stem cells — unspecialized cells that have the potential to form many different types of tissue. By turning on certain genes, the scientists attempt to coax the stem cells into becoming ... Read More about New stem cell pipeline makes more lifelike cell products
Health and Parenting
Teen having panic attack in public

Answers to six questions about anxiety in children and teens

Between school and social demands, lots of children feel stress, but at what point does anxiety cross the line and become a mental health concern? We sat down with Keneisha Sinclair-McBride, PhD, a clinical psychologist in the Department of Psychiatry at Boston Children’s Hospital, to better understand what separates serious forms of anxiety from normal worrying, ... Read More about Answers to six questions about anxiety in children and teens
Research
CRISPR hearing loss

Optimized CRISPR/Cas9 gene editing averts hearing loss in ‘Beethoven’ mice

Using a novel gene-editing approach, scientists at Boston Children’s Hospital and Harvard Medical School have salvaged hearing in a mouse model of hereditary deafness, with no apparent off-target effects. The system successfully identified a single misspelled “letter” in the defective copy of a gene required for hearing, disabled this aberrant copy, and spared the healthy ... Read More about Optimized CRISPR/Cas9 gene editing averts hearing loss in ‘Beethoven’ mice
Patient Stories
Erin, who had TGA, poses with her partner in Ireland

My continuing heart journey with Boston Children’s

My connection to Boston Children’s Hospital started on a bright and sunny June day in 1979. My parents, who were excitedly anticipating what they assumed would be the uncomplicated birth of their first child, got an unexpected surprise when I was born completely blue (like a Smurf) and had to be rushed to Boston Children’s. ... Read More about My continuing heart journey with Boston Children’s
Health and Parenting
Adult and child hands holding yellow gold ribbon

Common questions about childhood cancer, answered

Childhood cancer is rare, but when it happens, it usually brings up an endless stream of questions for parents. How did this happen? What will life be like for my child? In this episode of “Cancer Mythbusters” from Dana-Farber Cancer Institute, Dr. Allison O’Neill, clinical director of the Solid Tumor Program at Dana-Farber/Boston Children’s Cancer and Blood Disorder ... Read More about Common questions about childhood cancer, answered
Research
neuroblastoma

Overriding resistance to epigenetic inhibitors in neuroblastoma

Neuroblastoma and other children’s cancers pose unique challenges. They’re not caused by the same kinds of genetic mutations that cause adult cancers, and only a minority of their mutations can be targeted with drugs. In a recent study, a team led by Kimberly Stegmaier, MD, at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center systematically deleted every gene ... Read More about Overriding resistance to epigenetic inhibitors in neuroblastoma
Clinical Care
Huggable social robot versus alternatives

‘Huggable,’ a social robot for kids, eases hospital stress

Children confined to the hospital often feel lonely, bored, or scared, and must cope with pain and homesickness. They may not fully understand why they are there or what will happen next. Hours can feel like days. That’s where a robotic teddy bear called Huggable could come in, suggests a new study published today in ... Read More about ‘Huggable,’ a social robot for kids, eases hospital stress