Our Community
From local teams to elite athletics: Caring for youth athletes with disabilities
Anna Johannes considers herself lucky. “My swim coaches were oblivious to my disability — in a good way,” says the U.S. Paralympic medalist. Anna, who joined Boston Children’s Hospital as a cause marketing coordinator in 2018, was born with amniotic band syndrome, a condition that led to the loss of her left hand and forearm. ... Read More about From local teams to elite athletics: Caring for youth athletes with disabilities
Research
Meet BORIS: A new culprit in drug-resistant cancer?
Like a Russian bot corrupting U.S. elections, or a new prime minister wreaking havoc in the U.K., a protein named BORIS is showing itself to be a malevolent player in some childhood cancers. New research fingers BORIS as a culprit that can hack the neuroblastoma genome, rousing the cancer cells from dormancy after certain types ... Read More about Meet BORIS: A new culprit in drug-resistant cancer?
Clinical Care
In surgery for people with sepsis, choice of anesthetic may matter
Sepsis, an extreme immune response to infection, has no specific treatment and is a leading cause of hospital deaths. As part of their care, patients often undergo imaging procedures and surgery to pinpoint and help eliminate the infection. New preclinical findings suggest that the choice of general anesthetic used for these procedures can influence sepsis ... Read More about In surgery for people with sepsis, choice of anesthetic may matter
Research
How breast cancer uses exosomes to metastasize to the brain
Metastasizing breast cancers typically seek out the bones, lung, and brain. Brain metastases are especially dangerous; many women survive for less than a year after diagnosis. How is the cancer able to get past the blood brain barrier? And can it be blocked? Those questions led PhD candidate Golnaz Morad, DDS, and her mentor Marsha ... Read More about How breast cancer uses exosomes to metastasize to the brain
Research
How new loops in DNA packaging help us make diverse antibodies
Diversity is good, especially when it comes to antibodies. It’s long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies to conquer newly encountered threats. But how these gene segments come together to be spliced has been a mystery. ... Read More about How new loops in DNA packaging help us make diverse antibodies
Patient Stories
Nicole and Alana: A friendship formed in dance
I was holding myself back, scared I would hurt myself, but Alana helped me realize I could push myself safely. She helped me gain confidence and trust in my dancing body again.
Health and Parenting
Which genetic syndromes can increase a child’s risk of cancer?
Inherited cancers account for at least 5 to 10 percent of all pediatric cancers. The same advances in technology that have enabled scientists to decode the human genome now allow doctors to determine when a child has been born with an error (mutation) in a specific gene that puts them at increased risk of childhood ... Read More about Which genetic syndromes can increase a child’s risk of cancer?
Our Community
Staff Spotlight: Meet Jonette Jean-Louis
Jonette Jean-Louis is the program coordinator for the Midaortic Syndrome and Renovascular Hypertension Center at Boston Children’s Hospital. Midaortic syndrome is a rare but serious condition in which the part of the aorta (the heart’s largest blood vessel) that runs through the chest and abdomen becomes narrow. This can lead to lower blood flow in ... Read More about Staff Spotlight: Meet Jonette Jean-Louis
Patient Stories
Another level of gratitude: Spina bifida care for Liam
Most parents first walk through the doors of Boston Children’s Hospital seeking answers about their child’s health. But until recently, when Mary Holleran arrived at the hospital, she was simply beginning another day at work. A nurse practitioner, she’s been on staff at Boston Children’s for more than a decade, much of it spent caring ... Read More about Another level of gratitude: Spina bifida care for Liam
Patient Stories
After recovery from kidney cancer, Lia pays it forward
As a 3-year-old, Lia Scagnoli skipped across the “Bridge of Hope” connecting Boston Children’s Hospital and Dana-Farber Cancer Institute each time she had a chemotherapy infusion or other treatment for pediatric kidney cancer at Dana-Farber’s Jimmy Fund Clinic. Caregivers offering equal parts love, hope, and fun diversions gave her and her family a feeling of confidence ... Read More about After recovery from kidney cancer, Lia pays it forward