Archive for anesthesia
A bio-inspired approach to delivering local anesthetics
Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and muscles, and are an attractive alternative to opioids. But injected by themselves, the anesthetics can easily float away, causing severe systemic toxicity. Encapsulating these drugs in ... Read More
What parents should know about anesthesia
The prospect of surgery can be distressing to parents and kids alike, but the idea of a child undergoing anesthesia can be often be even more concerning to families. Still, many babies and young children need anesthesia to be able to tolerate tests, surgeries, and other minor invasive procedures. We asked anesthesiologist Dr. Joseph Cravero, ... Read More
In surgery for people with sepsis, choice of anesthetic may matter
Sepsis, an extreme immune response to infection, has no specific treatment and is a leading cause of hospital deaths. As part of their care, patients often undergo imaging procedures and surgery to pinpoint and help eliminate the infection. New preclinical findings suggest that the choice of general anesthetic used for these procedures can influence sepsis ... Read More
Fifty years as a Boston Children’s nurse
Mary Ellen Pierce, RN, MS, CPN, has been a nurse at Boston Children’s Hospital since 1969. She currently works in the Perioperative Care Coordination Clinic. I’ve been a nurse at Boston Children’s Hospital for almost 50 years, but this hospital has always been part of my life. When I was a kid, my father would ... Read More
Partnering with families to minimize exposure to anesthesia
In medicine, the best imaging can mean the difference between the right diagnosis and the wrong one. A successful treatment and an ineffective one. The radiology team at Boston Children’s Hospital carries out more than 200,000 imaging exams on children each year. Ranging in length from five minutes to two hours, all MRI scans require children to ... Read More
Safety trial of algal anesthetic kicks off
Two years ago, we told the story of the quest of Charles Berde, MD, PhD, of Boston Children’s Division of Pain Medicine, to turn an algal toxin called neosaxitoxin into a long-lasting local anesthetic. At that time, Berde—together with Alberto Rodríguez-Navarro, MD, from Padre Hurtado Hospital in Santiago, Chile, and a Chilean company called Proteus SA—already knew that ... Read More
Precision drug delivery systems could ‘trigger’ an age of nanomedicine
What if we could deliver biocompatible nanoparticles into the body and then activate them to release drugs exactly where they are needed, without causing side effects elsewhere? Scientists like Daniel Kohane, MD, PhD, of Boston Children’s Hospital, are developing nanoscale drug delivery systems to do just that, using a variety of materials and triggers that ... Read More
Safety trial of algal anesthetic kicks off
Two years ago, we told the story of the quest of Charles Berde, MD, PhD, of Boston Children’s Division of Pain Medicine, to turn an algal toxin called neosaxitoxin into a long-lasting local anesthetic. At that time, Berde—together with Alberto Rodríguez-Navarro, MD, from Padre Hurtado Hospital in Santiago, Chile, and a Chilean company called Proteus ... Read More
With algae blooms hope for a long-acting local anesthetic
For decades, Chile’s shoreline has had problems with periodic algal blooms – referred to as Red Tide, but actually containing a mix of microorganisms including bluegreen algae. Their toxins accumulate in shellfish, landing seafood consumers in the hospital, partially paralyzed, sometimes needing ventilators to breathe. The nerve block caused by the toxins is reversible, so ... Read More