As COVID-19 fuels opioid deaths, researchers look to create an anti-opioid vaccine
A project that began one year ago at Boston Children’s Hospital to develop an anti-opioid vaccine is starting to bear its first fruits. A team of addiction experts and vaccine developers across the Boston Children’s research community were recently awarded a $25 million research contract from the NIH’s Helping to End Addiction Long-term Initiative, or NIH ... Read More about As COVID-19 fuels opioid deaths, researchers look to create an anti-opioid vaccine
Too many blood cells: Probing a blood cancer’s genetic origins
At age 7, Meredith Shah began having debilitating migraine headaches. “I would have trouble seeing and shapes were blurry,” she recalls. “It was really painful.” Over time, the frequency and intensity of the headaches escalated. Her parents, Heidi and Nil, sought the help of multiple specialists. But they received few answers, other than an indication ... Read More about Too many blood cells: Probing a blood cancer’s genetic origins
The tiny choroid plexus protects the prenatal brain — but may also pass on inflammation from the mother
Floating in fluid deep in the brain are small, little-understood fronds of tissue. Two new studies reveal that these miniature organs are a hotbed of immune system activity. This activity may protect the developing brain from infections and other insults — but may also contribute to neurodevelopmental disorders like autism. Key takeaway This pioneering work ... Read More about The tiny choroid plexus protects the prenatal brain — but may also pass on inflammation from the mother
Scar-free healing after spinal cord injury relies on specialized cells
Key takeaways Scar tissue prevents nerves from communicating with each other. Microglia cells in the central nervous system help prevent scar tissue formation after spinal cord injuries in newborn mice. Transplanted newborn microglia cells drastically reduced scar formation in adult mice with spinal cord injury, opening the door to new treatment possibilities. One of the ... Read More about Scar-free healing after spinal cord injury relies on specialized cells
Two recent innovations in aerodigestive care
Feeding disorders are extremely common in pediatrics and are a source of significant stress for families. Because many complex feeding disorders lack treatment options, children tend to receive nutrition by feeding tubes as a result. The Aerodigestive Center at Boston Children’s Hospital has been at the forefront of developing novel therapies for feeding disorders. Two ... Read More about Two recent innovations in aerodigestive care
A diabetes drug with a potential side benefit: Reduced COVID-19 mortality
In 2006, the Food and Drug Administration approved the drug sitagliptin to lower blood sugar in type 2 diabetes. Now, a multicenter observational study in Italy suggests the drug also cuts mortality in diabetic patients hospitalized with COVID-19 — by as much as half. Paolo Fiorina, MD, PhD, of Boston Children’s Hospital led the study, ... Read More about A diabetes drug with a potential side benefit: Reduced COVID-19 mortality
Pain neurons activate immune cells, opening new treatment possibilities
For a long time, pain and inflammation were thought to be two separate biological responses. But new research by Boston Children’s Hospital and international collaborators suggests that the same sensory neurons that produce pain also trigger inflammation. And they do so by activating cells of the immune system, a relationship never described before. This interaction ... Read More about Pain neurons activate immune cells, opening new treatment possibilities
Platelet profiles could enhance care for bleeding disorders, cardiovascular disease, cancer
The trillion-odd platelets in our blood are best known for controlling bleeding, helping clots form when we sustain an injury. But platelets can also go rogue. They contribute to clotting in cardiovascular disease and diabetes, leading to strokes and heart attacks, and can be hijacked by cancers to help them spread. Key takeaways A new ... Read More about Platelet profiles could enhance care for bleeding disorders, cardiovascular disease, cancer
Global partnership leads to improved treatment for childhood diarrhea
Diarrheal diseases remain a major childhood health problem in many parts of the world. Each year, they lead to the deaths of more than 500,000 children under age 5 globally. A new large clinical trial based in Tanzania and India, led by investigators at Boston Children’s Hospital, local research universities, and the World Health Organization ... Read More about Global partnership leads to improved treatment for childhood diarrhea
Lung ‘organoids’ capture early-stage lung cancer; could help test treatments
Lung cancer, the leading cancer killer in the U.S., is often missed in its earlier stages. And while recent imaging advances offer earlier detection, early-stage lung cancers still have no targeted treatments. Key takeaways Mini “organoids” made from lung cells offer a rapid platform for tracking early-stage lung cancers and for testing possible treatments. RNA ... Read More about Lung ‘organoids’ capture early-stage lung cancer; could help test treatments