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A young child with a notebook with shapes scribbled in crayon.

Toddlers diagnosed with autism should be reevaluated over time

Clinical, Research
Parents whose child has been diagnosed with autism spectrum disorder (ASD) may feel it’s a lifelong label. But a new study offers hope: It found that 37 percent of children diagnosed as toddlers no longer met criteria for autism when they reached early school age. Findings were published October 2 in JAMA Pediatrics. Study leader ... Read More about Toddlers diagnosed with autism should be reevaluated over time
Tagged: autism, autism research, autism spectrum disorder, developmental medicine
Brielle Ferguson, PhD

Unraveling the secret to attention, one brain cell at a time: Brielle Ferguson, PhD

People, Research
In college, Dr. Brielle Ferguson was initially drawn to psychology. Witnessing the impact of schizophrenia on a family member, she was surprised how little was known about the condition. She majored in cognitive science, but she wanted to go deeper and understand what happens in the brain. Taking a required course in neuroscience, she thought, ... Read More about Unraveling the secret to attention, one brain cell at a time: Brielle Ferguson, PhD
Tagged: ADHD, autism spectrum disorder, epilepsy, neuroscience, research rising stars, schizophrenia
A Venn diagram shows interlocking circles of the heart, on left, and brain, with genetic code in background.

Research aims to pinpoint genetic connection between autism and heart disease

Basic/Translational, Research
Cardiology and neurodevelopmental researchers have more questions than answers about the possible genetic links between congenital heart disease (CHD) and autism spectrum disorder (ASD). A study that’s underway at Boston Children’s aims to pin down those elusive answers by taking a close look at the genetics of children with neurodevelopment and cardiovascular conditions. The researchers want to see ... Read More about Research aims to pinpoint genetic connection between autism and heart disease
Tagged: autism, autism research, autism spectrum disorder, cardiac neurodevelopment, cardiac research, congenital heart defect, genetics and genomics, heart, heart center, neurology, research
A Black mother and her newborn, with a DNA pattern to illustrate the BabySeq concept.

Bringing equity to genomic sequencing in newborns: BabySeq 2.0

Clinical Care, Research
Today, nearly 900 disorders caused by a single gene are known to be treatable. Yet the recommended “heel stick” testing for newborns only covers about 60 inherited, treatable disorders, and many individual states screen for fewer. What if newborns could instead have their entire genome sequenced at birth, with the results shared and acted on ... Read More about Bringing equity to genomic sequencing in newborns: BabySeq 2.0
Tagged: genetics and genomics, health equity, newborn medicine, well child care
The working end of the neurosurgical robot with its two arms.

This two-handed robot goes deep into the brain

Research, Therapeutics/Diagnostics/Devices
Robots have become common partners in the OR, enabling surgeons to operate through small incisions and manipulate tools endoscopically, avoiding invasive open surgery. But in neurosurgery, robots’ capabilities have been more limited. While they can assist with relatively simple procedures like inserting an electrode, more invasive and complex operations like removing a tumor still require ... Read More about This two-handed robot goes deep into the brain
Tagged: brain tumor, neurosurgery, robotics, surgery
A typical patient intake form covers medications, health conditions, but not marijuana use.

Does cannabis affect surgical outcomes? We need more data.

Clinical, Research
After alcohol, marijuana is the most commonly used recreational substance among U.S. adults and adolescents. Up to 22 million Americans 12 or older use cannabis. In a 2022 survey by the National Institute on Drug Abuse, 0.7 percent of 8th graders, 2.1 percent of 10th graders, and 6.3 percent of 12th graders reported using marijuana ... Read More about Does cannabis affect surgical outcomes? We need more data.
Tagged: informatics, orthopedics, spine division, surgery
Posed portrait of Maya Chopra

A global take on rare disease research: Maya Chopra, MBBS, FRACP

Clinical, Research
Several years ago, while working as a clinical geneticist at the Imagine Institute of Genetic Diseases in Paris, Dr. Maya Chopra saw a child with unexplained intellectual disability, a cleft palate, distinctive facial features, and an inability to speak. Through a genetic analysis, she and her colleagues identified a rare variant in one copy of ... Read More about A global take on rare disease research: Maya Chopra, MBBS, FRACP
Tagged: genetics and genomics, intellectual disability, neurology, neuroscience, rare disease, research rising stars
Five Boston Children's heart team members look at the image of a 3D heart model on a large wall screen.

From aerospace to the OR: 3D modeling improves surgical planning by revealing details of patients’ hearts

Clinical
One of the most important tools for complex heart surgeries at Boston Children’s isn’t even in the operating room. For years, heart surgeons couldn’t see the complete extent of a patient’s condition until a procedure started, forcing them to rely on experience, diagnostic imaging, and other information to plan surgery. Now, 3D modeling allows them ... Read More about From aerospace to the OR: 3D modeling improves surgical planning by revealing details of patients’ hearts
Tagged: atrial septal defect, cardiac research, cardiac surgery, congenital heart defect, heart, heart center, imaging, single ventricle defects
AML leukemia cells intermingled with healthy blood stem cells, which are bearing shields.

Making immunotherapy safe for AML

Basic/Translational, Research
Acute myeloid leukemia (AML), the second most common leukemia in children, is hard to treat and has a five-year survival rate of just 65 to 70 percent, according to the American Cancer Society. While immunotherapies like monoclonal antibodies or CAR T-cell therapy are effective for certain blood cancers, they have not been possible in AML ... Read More about Making immunotherapy safe for AML
Tagged: cancer, car t-cell therapy, gene editing, gene therapy, immunotherapy, stem cell transplant
Two physicians study an image of the bones and ligaments of the knee.

Uncertainty surrounds ACL treatment decisions in young athletes. It shouldn’t.

Clinical, Research
It’s an injury once seen mainly in adults, yet it’s become increasingly common in younger patients. From 2000 to 2020, the number of anterior cruciate ligament (ACL) tears in children and adolescents increased between three- and five-fold. For young athletes, an ACL tear spells six to nine months of downtime, heightened risk for secondary ACL ... Read More about Uncertainty surrounds ACL treatment decisions in young athletes. It shouldn’t.
Tagged: acl, orthopedics, sports injury, sports medicine, surgery

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