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The surprising energy demands of marathon training

Posted on by | Health and Parenting
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Training for a marathon? Are you eating enough to help your body recover from one long training run and gear up for the next one? A surprising number of marathon runners don’t. In a study of athletes training for the Boston Marathon, more than two in five women and almost one in five men regularly ... Read More
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Could peripheral neuropathy be stopped before it starts?

Posted on by | Basic/Translational, Research
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An increase in high-fat, high-fructose foods in people’s diets has contributed to a dramatic increase in type 2 diabetes. This, in turn, has led to an increase in peripheral neuropathy — nerve damage, typically in the hands and feet — that causes weakness, loss of sensation and, in some, a stabbing, burning, or tingling pain. ... Read More
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Every heart has a story. See how we care for them all.

Posted on by | Patient Stories
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It’s easy to think of the heart as a common denominator — everyone has one — but no two hearts are alike. Every heart is different. Every heart has a story. For many children and adults, that story includes coming to Boston Children’s for specialized heart care. Some were born with complex congenital heart defects, while ... Read More
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It’s all in the PV loops: New analytical model could improve circulation assessments before heart surgery

Posted on by | Clinical, Research
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The double-switch operation corrects the congenital reversal of the heart’s ventricles and its two main arteries. It’s a practical way of putting the ventricles into the position they belong so that children with congenitally corrected transposition of the great arteries (CC-TGA) can benefit from enhanced circulation. Surgery, though, doesn’t come without risks. Some children’s left ventricles — ... Read More
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Modifying macrophages in the lung could head off pulmonary hypertension

Posted on by | Basic/Translational, Research
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In the 1980s, when Stella Kourembanas, MD, began her career in neonatology, she cared for newborns with pulmonary hypertension, a disease that results in abnormally high blood pressure in the lung arteries and can lead to heart failure. Since then, treatments like inhaled nitric oxide, new vasodilators, new modalities of mechanical ventilation, and extracorporeal membrane ... Read More
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A new tool could exponentially expand our understanding of bacteria

Posted on by | Basic/Translational, Research
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How do bacteria — harmless ones living in our bodies, or those that cause disease — organize their activities? A new study, combining powerful genomic-scale microscopy with a technical innovation, captured which genes bacteria turn on in different situations and in different spatial environments. The technology, described January 23 in Science, promises to take the ... Read More
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MRI could reduce the mystery of brachial plexus injuries in infants

Posted on by | Clinical, Research
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About one in 1,000 children are born with brachial plexus birth injury (BPBI), upper extremity weakness or paralysis resulting from trauma to the brachial plexus nerves during childbirth. Most children with BPBI recover with observation and minimally invasive care, but about 30 percent have injuries severe enough to lead to long-term impairment. Thanks to recent ... Read More
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Unstoppable: Flatfoot correction helps Jacob take control

Posted on by | Patient Stories
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The first time Dr. Susan Mahan examined Jacob’s feet, she pressed on a tender spot near one of his arches. “You see that?” Jacob’s mother, Lucie, remembers her saying. “That bone isn’t supposed to be there.” Jacob was 13 and had spent a frustrating year trying to figure out why basketball, his greatest source of ... Read More
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Bringing order to disorder: Jhullian Alston, PhD

Posted on by | People, Research
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Proteins typically fold into orderly, predictable three-dimensional structures that dictate how they will interact with other molecules. Jhulian Alston, PhD, is drawn to intrinsically disordered proteins, whose key feature is a lack of structure. They are difficult to study and far less explored. “They’re floppy, they don’t have specific folds, they can’t slot into each ... Read More
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My son is a NICU GraD: Here’s what I’ve learned

Posted on by | Health and Parenting, Patient Stories
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My husband and I aren’t first-time parents, but when our twins were born nine weeks early a year ago, everything we thought we knew went out the window. The thing is, it wasn’t Cal and Theo’s early arrival that was the biggest shock; it was the challenges that came afterward. Life with newborns and a ... Read More
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