Archive for imaging
Sturdier spikes may explain SARS-CoV-2 variants’ faster spread
The fast-spreading U.K., South Africa, and Brazil variants are raising concerns and questions about whether current COVID-19 vaccines will protect against them. A structural biology study led by Bing Chen, PhD, at Boston Children’s Hospital now reveals how the D614G mutation — carried by all three variants — makes SARS-CoV-2 spread faster. Key takeaways: The main ... Read More about Sturdier spikes may explain SARS-CoV-2 variants’ faster spread
At the forefront of kidney stone removal: Innovative approaches transform patient care
No longer considered just an adult problem, kidney stones increasingly affect children as well. The majority of children who cannot pass stones on their own can be treated with minimally invasive approaches such as extracorporeal shock wave lithotripsy, ureteroscopy, percutaneous nephrolithotomy, laparoscopic and robotic approaches and, rarely, open surgery. Now, two recent innovations provide additional ... Read More about At the forefront of kidney stone removal: Innovative approaches transform patient care
Capturing SARS-CoV-2’s shape-shifting spike protein
The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic. The spikes bind to human cells via the ACE2 receptor and then dramatically change shape. They jack-knife, folding in on themselves to fuse their own membrane with the membrane of our cells. And that opens ... Read More about Capturing SARS-CoV-2’s shape-shifting spike protein
Monitoring for breast cancer after childhood chest radiation: When and how?
Chest radiation is used to treat children with Hodgkin and non-Hodgkin lymphoma as well as lung metastases in various solid tumors. But radiation itself is a potential cancer risk. That includes an increased risk for breast cancer later in life. Girls receiving chest radiation for childhood cancer face a breast cancer risk as high as ... Read More about Monitoring for breast cancer after childhood chest radiation: When and how?
Guidance for assessing treatment response in pediatric brain tumors
Assessing patients’ response to cancer therapy can be challenging, especially in neuro-oncology. Generally, we assess treatment response by a change in tumor size on MRI scan. However, with brain tumors, changes on MRI scan can be difficult to interpret. A decrease in tumor size may indicate treatment is having an effect; however, a drug can ... Read More about Guidance for assessing treatment response in pediatric brain tumors
Radiology of COVID-19 infection in children: Imaging findings and recommendations
Key takeaways:· Lung images in children with COVID-19 show unique features, including the halo sign.· Chest X-ray and CT images differ significantly from early to late infection.· New imaging guidelines recommend when to perform imaging studies on children with COVID-19. As more children become infected with the coronavirus causing COVID-19, lung imaging shows that the ... Read More about Radiology of COVID-19 infection in children: Imaging findings and recommendations
Going into science: Women scientists at Boston Children’s offer advice to girls
In honor of the International Day of Women and Girls in Science (February 11), we invited women scientists at all stages of their careers at Boston Children’s Hospital to share their scientific agendas. Here is some of what they had to say. The scientists also offered their advice for girls interested in entering the field. ... Read More about Going into science: Women scientists at Boston Children’s offer advice to girls
The Beauty of the Brain
Every year, the Harvard Brain Science Initiative sponsors its Beauty of the Brain contest. This year, two Boston Children’s Hospital images are among the six winners drawn from a pool of forty submissions. Above, Mary Whitman, MD, PhD, and Jess Bell, from the laboratory of Elizabeth Engle, MD, developed this image of a developing mouse ... Read More about The Beauty of the Brain
PET imaging shows if PD-1 cancer immunotherapy is working
PD-1 is a protein on our T cells that normally keeps these immune cells from running amok. A growing number of cancer drugs are designed to inhibit PD-1, enabling patients’ T-cells to attack and kill cancerous cells. PD-1 blockers such as pembrolizumab (Keytruda) have been helpful in treating several cancers including melanoma, non-small cell lung ... Read More about PET imaging shows if PD-1 cancer immunotherapy is working
First sharp images reveal structure of key inflammatory protein
After decades of attempts by the scientific community, researchers have now provided the first clear look at a protein implicated in a vast array of inflammatory conditions. The finding, published recently in Nature, lifts a blindfold that has hampered scientists’ ability to intervene when the immune system overreacts to perceived threats. The protein, known as ... Read More about First sharp images reveal structure of key inflammatory protein