Archive for cancer
Poverty predicts worse cancer outcomes, even in children receiving top-tier care
A pair of recent studies suggests that even among patients receiving advanced cancer care, poverty is a predictor of worse outcomes. The disturbing findings raise many questions that follow-up studies are now exploring. Key takeaways Poverty was associated with 3.7-fold higher mortality among children receiving targeted immunotherapy for high-risk neuroblastoma. Household poverty was associated with ... Read More
Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal and in great need of better treatments. Only about 10 percent of patients remain alive five years after diagnosis. In a new study, researchers in the lab of Marsha Moses, PhD, at Boston Children’s Hospital offer a glimmer of hope. Key takeaway An antibody-drug combination effectively targeted, penetrated, and shrank ... Read More
Dancer stays on toes during kidney cancer treatment
Carly Tobin loves dancing for the fun and freedom it provides. During treatment for a rare pediatric kidney cancer known as Wilms tumor, the pre-teen’s passion also proved a vital source of strength. Diagnosed in early June 2019, Carly — now 11 and cancer-free — underwent surgery, radiation, and chemotherapy at Dana-Farber/Boston Children’s Cancer and Blood ... Read More
One in 5 million: Nathan’s rare diagnosis and happy recovery
Nathan Asselin was a happy baby with no apparent health problems when he became ill just before his birthday in April of this year. “He didn’t seem himself the night before, then he woke up with a fever on the day of his birthday,” says his mother, Danielle. “He sat on the floor eating his ... Read More
CAR T-cell therapy helps young hockey fan ice pediatric leukemia
Due to COVID-19, Ava Girolimetti wasn’t sure if she would be starting middle school this year in a classroom, on a computer screen, or a combination of both. But thanks to CAR T-cell therapy for acute lymphoblastic leukemia (ALL), she knew she would be there cancer-free. The rising sixth grader can make this claim as ... Read More
Lung ‘organoids’ capture early-stage lung cancer; could help test treatments
Lung cancer, the leading cancer killer in the U.S., is often missed in its earlier stages. And while recent imaging advances offer earlier detection, early-stage lung cancers still have no targeted treatments. Key takeaways Mini “organoids” made from lung cells offer a rapid platform for tracking early-stage lung cancers and for testing possible treatments. RNA ... Read More
Crista forms lifelong friendship with her cancer doctor
It’s impossible not to notice the connection between Crista Cardillo and Dr. Kim Stegmaier. The way they laugh and swap stories might make you think they grew up down the street from one another. But their friendship began differently than most: as patient and oncologist at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. When Crista was ... Read More
Bone cancer surgery: A difficult choice
Nolan and Natasha might never have met if they hadn’t been diagnosed with bone cancer. Nolan, 13, is a natural athlete who lives in Maine. Natasha, 11, lives in Rhode Island and loves music and theater. As kids go, the two are pretty different — except for their osteosarcoma diagnoses and the surgery to remove ... Read More
Diving into the dark side of ependymoma
Mariella Filbin, MD, PhD, a neuro-oncologist at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, is driven by a desire to find new therapies for some of the hardest-to-treat pediatric brain tumors. At the core of her work is an effort to uncover the events that shape tumor development. Key takeaways:· Aggressive ependymoma tumors are stuck ... Read More
Monitoring for breast cancer after childhood chest radiation: When and how?
Chest radiation is used to treat children with Hodgkin and non-Hodgkin lymphoma as well as lung metastases in various solid tumors. But radiation itself is a potential cancer risk. That includes an increased risk for breast cancer later in life. Girls receiving chest radiation for childhood cancer face a breast cancer risk as high as ... Read More