Research
Zika study reveals how infection can cause microcephaly
Prenatal exposure to viruses capable of infecting the fetal brain, particularly in the first trimester, can cause a range of developmental defects in the baby. The Zika epidemic in Brazil during 2015-2016 posed an extreme case, causing hundreds of babies to be born with microcephaly, or an abnormally small head. Although cases have waned significantly, ... Read More about Zika study reveals how infection can cause microcephaly
Research
Studies pinpoint risk factors for complications of pediatric intestinal failure
Pediatric intestinal failure occurs when patients lack the amount of intestine necessary for growth and development. As advances in treatment have led to better survival rates for children with short bowel syndrome and other forms of intestinal failure, the team at Boston Children’s Center for Advanced Intestinal Rehabilitation (CAIR) is studying factors that affect quality ... Read More about Studies pinpoint risk factors for complications of pediatric intestinal failure
Patient Stories
How Josie’s bad day turned into a campaign to help kids with scoliosis
Josephine DeFilippi (Josie) describes the day of her scoliosis diagnosis as the hardest day of her life. Right when she was looking forward to middle school, ten-year-old Josie was shocked to learn she had a condition she’d never even heard of before. On that same day, however, an unexpected gift from someone she’d never met ... Read More about How Josie’s bad day turned into a campaign to help kids with scoliosis
Health and Parenting
July 2023 coloring pages
Chase away rainy-day boredom with this month’s coloring pages, brought to you by Boston Children’s! Coloring_Summer_BeachDownload Coloring_Summer_BikeDownload Coloring_Summer_InsectsDownload Images: Adobe Stock/Illustration: David Chrisom Get more coloring pages, news, and tips for your family from our weekly newsletter. Sign up now! Share this:
Research
Tackling an aggressive, treatment-resistant lymphoma where it lives
Anaplastic large cell lymphoma, a form of non-Hodgkin lymphoma, is the most common aggressive lymphoma in children. Chemotherapy and radiation fail to cure about 30 percent of cases. When tumors are driven by the oncogene ALK — which is the case for the majority of children — kinase inhibitor drugs like crizotinib are very effective ... Read More about Tackling an aggressive, treatment-resistant lymphoma where it lives
Research
One-time treatment could block a deadly form of graft-versus-host disease
Even when a bone marrow transplant cures leukemia or lymphoma, patients can still pass away from graft-versus-host disease (GVHD), in which T cells in the donor graft attack the recipient’s own tissues. Leslie Kean, MD, PhD, director of stem cell transplant at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, has long sought to prevent this ... Read More about One-time treatment could block a deadly form of graft-versus-host disease
Research
From bench to bedside: A promising option for unremitting ulcerative colitis
Many existing treatments for inflammatory bowel disease, like Remicade® and Humira®, work by blocking inflammatory cytokines such as tumor necrosis factor (TNF) and interleukins IL-12 and IL-23, which are over-produced in autoimmune disease. But few patients with ulcerative colitis get complete relief from these drugs. A small but promising open-label clinical trial, published recently in ... Read More about From bench to bedside: A promising option for unremitting ulcerative colitis
Research
Perfecting the craft of modeling disease in stem cells: Dosh Whye
Part of an ongoing series profiling researchers at Boston Children’s Hospital. Dosh Whye has always wanted to make peoples’ lives better, but he never imagined that tending to stem cells in a lab seven days a week would be the way he would do it. Now, as an assistant director of the Human Neuron Core ... Read More about Perfecting the craft of modeling disease in stem cells: Dosh Whye
Research
Seeking a path forward for custom genetic treatments
In 2018, at age 7, Mila Makovec became the world’s first person to be treated with a drug made just for her. Languishing from Batten disease, a rare, fatal neurodegenerative disorder, she received an antisense oligonucleotide (ASO) drug designed to silence her genetic mutation, injected into the fluid around her spine through a lumbar puncture. ... Read More about Seeking a path forward for custom genetic treatments
Patient Stories
Not just another patient: Care for midaortic syndrome that’s ‘handcrafted’ for Iris
This past July, Iris Huot, her older sister, Audrey, and their parents, Jessica and Austin, gathered around their dining room table. To an outsider, it might seem like an ordinary dinner, but for the Huots, it was a moment of perspective — and gratitude. “It was the first time in eight weeks that we had ... Read More about Not just another patient: Care for midaortic syndrome that’s ‘handcrafted’ for Iris