Archive for research
Making pediatric health equity research truly equitable: An EDI review process
A burgeoning number of studies are examining pediatric health equity, diversity, and inclusion (EDI). But if not done right, health equity research can do a disservice, perpetuating biases and wrong assumptions that actually exacerbate inequities. To guide EDI-related studies, the Institutional Review Board (IRB) at Boston Children’s Hospital (through Tina Young Poussaint, MD, and Susan ... Read More about Making pediatric health equity research truly equitable: An EDI review process
Will early intervention prevent asthma in school-age children?
Asthma affects about 1 in 10 children, often sending them to the emergency room or causing them to miss school. Allergic conditions in young children — like food allergies or eczema — are often a precursor. Susceptible children begin producing IgE antibodies, which trigger allergic reactions and spur the “allergic march” toward asthma. IgE antibodies ... Read More about Will early intervention prevent asthma in school-age children?
Finding a possible genetic treatment for rare arrhythmias
Variants in a gene that plays a key role in heart function can cause potentially life-threatening arrhythmia syndromes known as calmodulinopathy. Calmodulinopathy is rare and causes arrhythmias that are poorly treated by current options. Boston Children’s cardiologist William Pu, MD, believes he has found a promising custom genetic treatment: antisense oligonucleotides that deplete the disease-causing gene product. ... Read More about Finding a possible genetic treatment for rare arrhythmias
New insight into the effects of PPIs in children
Proton-pump inhibitors (PPIs) are frequently prescribed to suppress stomach acid in patients with gastroesophageal reflux disease (GERD). Prescribing rates of PPIs in children have risen more than 500 percent in the past two decades, despite growing concerns about their risks: Previous research has linked their use to an increased risk of various pulmonary and gastrointestinal ... Read More about New insight into the effects of PPIs in children
Immunotherapy for children with primary liver carcinomas: Research offers new hope
Pediatric hepatocellular carcinoma (HCC) and fibrolamellar carcinoma are rare, aggressive forms of liver cancer that typically affect adolescents and young adults. Although some immunotherapy drugs are approved by the Food and Drug Administration as first-line treatments for HCC in adults, less is known about their effectiveness in treating pediatric liver carcinomas. Now, new research led ... Read More about Immunotherapy for children with primary liver carcinomas: Research offers new hope
Finding epilepsy hotspots before surgery: A faster, non-invasive approach
Neurosurgery for patients with drug-resistant epilepsy requires locating the precise brain areas that are generating the seizures. Typically, patients undergo 7 to 10 days of invasive intracranial EEG monitoring, with electrodes surgically implanted inside the brain through one or more skull openings to capture seizure activity as it happens. Eleonora Tamilia, PhD, directs the Epilepsy ... Read More about Finding epilepsy hotspots before surgery: A faster, non-invasive approach
Firearm suicides in children and youth: A state-by-state look
At a time when mental health problems are skyrocketing, a new study provides one of the most comprehensive state-by-state accountings to date of firearm suicides in children and youth. The findings, published in JAMA Pediatrics, are eye-opening — but could also help in crafting interventions. Lois Lee, MD, MPH, in the Division of Emergency Medicine ... Read More about Firearm suicides in children and youth: A state-by-state look
The gut-brain connection: A new approach to OCD and tic disorders?
It’s natural for young children to use routines to help them navigate the world and for older children and teens to zero in on interests and hobbies. But if they veer into disruptive, unwanted obsessions or thoughts or the need to perform compulsive rituals, they may have obsessive-compulsive disorder (OCD). We know that OCD is ... Read More about The gut-brain connection: A new approach to OCD and tic disorders?
Can we prevent seizures in Sturge-Weber syndrome?
Port wine stains — capillary malformations on the skin — are the most visible manifestation of Sturge-Weber syndrome. However, up to 60 percent of babies with birthmarks in high-risk locations (forehead and upper eyelid) also have capillary malformations in their brain. Of these, 75 to 90 percent will experience a seizure before the age of 2, ... Read More about Can we prevent seizures in Sturge-Weber syndrome?
Helping Jasmine manage Sturge-Weber syndrome before symptoms start
Sturge-Weber syndrome is a rare neurovascular disorder that increases the risk of seizures in infants due to abnormal blood vessel development in the brain. Almost 90 percent of children with Sturge-Weber experience their first seizure before age 2, which makes proactive, seizure-preventive care important in minimizing the risk of long-term brain injury. Finding such care, ... Read More about Helping Jasmine manage Sturge-Weber syndrome before symptoms start