Research
Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal and in great need of better treatments. Only about 10 percent of patients remain alive five years after diagnosis. In a new study, researchers in the lab of Marsha Moses, PhD, at Boston Children’s Hospital offer a glimmer of hope. Key takeaway An antibody-drug combination effectively targeted, penetrated, and shrank ... Read More about Precision chemo-immunotherapy for pancreatic cancer?
Research
Why do some children exposed to the coronavirus go on to develop MIS-C?
Most children exposed to the SARS-CoV-2 coronavirus have few or no symptoms. But a small number become sick enough to go to the hospital. And a tiny handful develop a severe inflammatory illness called multisystem inflammatory syndrome (MIS-C), often weeks after initial exposure to the virus. Why? A team at Boston Children’s Hospital is using ... Read More about Why do some children exposed to the coronavirus go on to develop MIS-C?
Clinical Care
Remdesivir: What to know about the first drug approved to treat COVID-19
In late October, the U.S. Food and Drug Administration (FDA) officially approved the antiviral drug remdesivir (Veklury) for COVID-19. The approval has been controversial, with many scientists questioning the strength of the evidence and proposing that the drug undergo further clinical trials before receiving full FDA approval . What does this mean for children who ... Read More about Remdesivir: What to know about the first drug approved to treat COVID-19
Research
Chromatin regulation enables generation of diverse antibodies
We need a variety of antibody types to help fight off invading foreign pathogens and our genome is exquisitely tuned to produce them to meet emerging needs. A new study finds that not just our DNA, but its configuration and packaging, help us generate diverse antibodies. Key takeaways Chromatin loop extrusion leads to creation of ... Read More about Chromatin regulation enables generation of diverse antibodies
Health and Parenting
Preparing your kids for the holidays during COVID-19
Like most things this year, the holiday season will be marked by the coronavirus pandemic. For you and your family, it may feel like one more disappointment at the end of a long, challenging year. So, how do you talk with your kids about the upcoming holidays? And what can you do to celebrate, even ... Read More about Preparing your kids for the holidays during COVID-19
Research
Study: Even strict gluten-free diets may not completely prevent gluten exposure
Even a strict gluten-free (GF) diet may not help people with celiac disease completely avoid gluten. That’s the finding of a recent study by Jocelyn Silvester, MD, PhD, and her colleagues at the University of Manitoba, Beth Israel Deaconess Medical Center, and the University of Seville. They sought to determine whether GF diets still contain ... Read More about Study: Even strict gluten-free diets may not completely prevent gluten exposure
Patient Stories
PK deficiency clinical trial: Jim’s volleyball ace
Growing up with pyruvate kinase deficiency (PK deficiency) wasn’t always the easiest thing, but it was my reality. My visits to Dana-Farber/Boston Children’s Cancer and Blood Disorders Center helped give me perspective — although my condition was difficult to deal with, it certainly was not the worst condition I could have. It made me grateful ... Read More about PK deficiency clinical trial: Jim’s volleyball ace
Health and Parenting
Let them play: Why free play is crucial for kids
As the school season winds down, you may be wondering how to keep your kids busy if they’re home all day. Consider letting them play. What is free play? Free play is any type of unstructured play that is directed by the child. It helps children develop their imaginations while experiencing and exploring the world ... Read More about Let them play: Why free play is crucial for kids
Research
New strategies for restoring myelin on damaged nerve cells
Key takeaways Myelin is an essential fatty substance coating surrounding nerve axons. After injury, regenerated nerve axons usually fail to remyelinate, inhibiting nerve cell communication. A combination treatment led to remyelination in about 60 percent of regenerated axons. This research may have implications in other diseases associated with myelin loss, like multiple sclerosis. Loss of ... Read More about New strategies for restoring myelin on damaged nerve cells
Research
COVID-19 virus levels in children: Differences between asymptomatic vs. symptomatic kids
A new study finds that most asymptomatic children who tested positive for COVID-19 had lower levels of the virus compared to symptomatic children. While it is the first large and comprehensive investigation of its kind in asymptomatic children, several important questions remain unanswered. Nira Pollock “Our study did show that asymptomatic children had lower viral ... Read More about COVID-19 virus levels in children: Differences between asymptomatic vs. symptomatic kids