Research
Partnering diet and intestinal microbes to protect against GI disease
Despite being an everyday necessity, nutrition is something of a black box. We know that many plant-based foods are good for us, but we don’t always know why. Our intestinal microbiome, which helps break down these foods once we consume them, is another black box. What role do our gut bacteria play? Seth Rakoff-Nahoum, MD, ... Read More about Partnering diet and intestinal microbes to protect against GI disease
Clinical Care
When to refer a pediatric patient for endometriosis
Endometriosis is a complex disease in which endometrium-like tissue grows in locations such as the fallopian tubes, ovaries, or pelvic tissue, leading to serious pelvic pain and other symptoms. Although there is a common assumption that the disease only affects adults, approximately two-thirds of people with endometriosis report that their symptoms were present before age ... Read More about When to refer a pediatric patient for endometriosis
Patient Stories
‘What I want you to know about endometriosis’: Iva’s story
Growing up, I heard stories about how everyone’s first period is usually no big deal. The cramps, the fatigue, the cravings—just uncomfortable to most. But my first period at age 11 brought excruciating pain that caused me to double over and wonder if I was the only one who experienced this. I had “the talk” ... Read More about ‘What I want you to know about endometriosis’: Iva’s story
Research
Past patient outcomes could help single-ventricle surgery decisions
When considering whether a child who has a single-ventricle heart defect would benefit more from biventricular repair or the Fontan procedure, heart specialists have lacked a key tool to guide them: data that shows possible long-term health risks of each surgical option. But Boston Children’s heart specialists — who perform biventricular repair more often than any other pediatric hospital — ... Read More about Past patient outcomes could help single-ventricle surgery decisions
Clinical Care
Are weight-loss medications and surgery right for teens?
Advances in bariatric surgery and weight-loss medications have made weight management accessible to more adults. But are these approaches effective — and safe — for teens, too? Weight-management medications, particularly glucagon-like peptide 1 receptor agonists (GLP-1RAs), are the newest tool available to people over age 12 for the treatment of obesity and related conditions. At ... Read More about Are weight-loss medications and surgery right for teens?
Research
Pediatric high-grade gliomas: Research reveals effective targeting with avapritinib
Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas. Not only are genetic alterations of PDGFRA common in patients with ... Read More about Pediatric high-grade gliomas: Research reveals effective targeting with avapritinib
A better treatment for endometriosis could lie in migraine medications
Endometriosis is a common, mysterious, often painful condition in which tissue similar to the uterine lining grows outside the uterus, forming lesions in locations such as the fallopian tubes, ovaries, and pelvis. These lesions can cause severe pain during periods, heavy menstrual bleeding, pelvic or abdominal pain, and sometimes painful bowel movements and urination. Existing ... Read More about A better treatment for endometriosis could lie in migraine medications
Patient Stories
‘They never stopped trying to figure out what was happening’: RyennAnne’s encephalitis journey
When 5-year-old RyennAnne Hurst developed a bad sore throat last summer, her doctor thought she might have strep and prescribed her antibiotics. But two weeks later, she wasn’t feeling any better. In fact, she was lethargic and her head hurt. “She told us it felt like something was smashing into the right side of her ... Read More about ‘They never stopped trying to figure out what was happening’: RyennAnne’s encephalitis journey
Patient Stories
Pirate puzzles and peekaboo: Beckett’s brachial plexus birth injury story
Beckett Stone-Lyman is an adorable, fun 2-year-old who loves to run, sprint, and climb. If he’s not charging around the playground, he’s probably doing a pirate puzzle. Or maybe he’s staring at his fingers as he wiggles them, amazed that his right hand can now do many of the same things as his left. Thanks ... Read More about Pirate puzzles and peekaboo: Beckett’s brachial plexus birth injury story
Patient Stories
A fall from a swing uncovers a rare cervical spine condition: Charlotte’s story
If it were any other year, Charlotte Gillis would have celebrated her 10th birthday in mid-July with a big party. But in June 2024, a fall from a swing had left her temporarily paralyzed. Though her mobility returned within a few hours, she was still in a neck brace, still wobbly on her feet, and ... Read More about A fall from a swing uncovers a rare cervical spine condition: Charlotte’s story