Research
Dually-targeted liposomes curb triple-negative breast cancer, metastases in mice
Some 15 to 20 percent of all breast cancers are triple-negative, meaning they lack receptors for estrogen, progesterone and human epidermal growth factor type 2. They have the worst prognosis of all breast cancers and very limited treatment options. Finding a treatment that distinguishes between cancer cells and normal cells has been especially challenging. A ... Read More about Dually-targeted liposomes curb triple-negative breast cancer, metastases in mice
Health and Parenting
Noisy breathing? It could be tracheomalacia
DJ is at his pediatrician’s office with his third bout of pneumonia this year. Katie wants to play soccer, but gasps for air when she exerts herself. Sarah’s parents have learned CPR because she has stopped breathing so many times. Although these kids appear to have very different problems, they all have one underlying cause: tracheomalacia. ... Read More about Noisy breathing? It could be tracheomalacia
Health and Parenting
Four things I learned at the Cardiac Neurodevelopmental Family Symposium
I’m sure most parents treat clinic visits as I do… an opportunity to get every last drop of information out of your child’s doctors while you have their undivided attention. So, when the opportunity presents, you take advantage of a full day of learning about your kiddo. I had that chance recently — along with ... Read More about Four things I learned at the Cardiac Neurodevelopmental Family Symposium
Our Community
Teens teach other teens healthy habits in Waltham
Learning how to eat healthier. Finding more time for physical activity. Coping with challenges and setbacks. These are all skills that teens need to learn … but from whom? The Waltham Boys & Girls Club believes it has hit on an answer: other teens. A grant from Boston Children’s Collaboration for Community Health will fund a campaign in which ... Read More about Teens teach other teens healthy habits in Waltham
Patient Stories
Cole: Having a ball after CAR T-cell therapy
After undergoing a promising new treatment for acute lymphoblastic leukemia (ALL), Cole Malone is back to doing what he loves: playing on a flag football team with his twin brother, Michael. Cole and Michael, 14, already know plenty about teamwork. Michael served as a perfect-match donor when Cole had a stem cell transplant at Dana-Farber/Boston Children’s Cancer and Blood ... Read More about Cole: Having a ball after CAR T-cell therapy
Patient Stories
The space between heartache and happiness: Two sons with adrenoleukodystrophy
When Paul and Liliana Rojas talk about their life, they describe it in one of two ways — the way it was before their sons, 10-year-old Brandon and 7-year-old Brian, were diagnosed with ALD, and the way it is after. Their story is one of heartbreak — but also hope, in the form of a ... Read More about The space between heartache and happiness: Two sons with adrenoleukodystrophy
Patient Stories
Manny: Hoping new research helps others with sickle cell disease
Emmanuel “Manny” Johnson, Jr., shares many loves with his little brother, Aiden — from basketball to video games. One thing he wishes they did not share is sickle cell disease (SCD), so Manny is playing a role in a new effort to improve treatment for patients like 7-year-old Aiden, himself and others living with the inherited blood disorder. ... Read More about Manny: Hoping new research helps others with sickle cell disease
Research
How the antidepressant ketamine rapidly awakens the brain, and why its effects vary more in women
In small doses, the anesthetic ketamine is a mildly hallucinogenic party drug known as “Special K.” In even smaller doses, ketamine relieves depression — abruptly and sometimes dramatically, steering some people away from suicidal thoughts. Studies indicate that ketamine works in 60 to 70 percent of people not helped by slower-acting SSRIs, the usual drugs ... Read More about How the antidepressant ketamine rapidly awakens the brain, and why its effects vary more in women
Research
I-ACQUIRE: A new study for young stroke patients
Could I-ACQUIRE help your child?To qualify for this study, your child must meet the following criteria: · is 8 to 36 months old · had a perinatal arterial ischemic stroke confirmed by MRI · has weakness on one side of the body both arm and leg · is in good health · hasn’t had previous ... Read More about I-ACQUIRE: A new study for young stroke patients
Research
Drug repurposing and DNA mining: The hunt for new endometriosis treatments
Endometriosis is a common gynecological condition that may affect more than 1 in 10 reproductive-age women. Yet, there’s very little research into the disease and limited options for treatment. A team in the Vascular Biology Program at Boston Children’s Hospital is trying to change that. In endometriosis, tissue that normally grows inside the uterus grows outside of ... Read More about Drug repurposing and DNA mining: The hunt for new endometriosis treatments