It takes a village: Creating best practices for personalized treatments
In 2019, doctors and scientists at Boston Children’s Hospital announced a medical landmark. In the space of one year, a team led by Timothy Yu, MD, PhD, pinpointed a one-of-a-kind genetic mutation in a girl named Mila with Batten disease, developed a custom drug called milasen to repair the mutation, and treated Mila with it. ... Read More
Solving neurodevelopmental mysteries, one gene, one child at a time
Suheil Day was born early, at 37 weeks. Aside from a slight head lag and mild muscle weakness, nothing seemed terribly amiss. But as the months progressed, he began having seizures. “At the age of 4 to 5 months, he started waking up screaming and crying excessively, his eyes rolling up into his head,” says ... Read More
Fingers, shoulders, and everything in between: Three upper extremity surgeons and their relentless quest for solutions
It’s 6 a.m. and the surgeons in the Hand and Orthopedic Upper Extremity Program at Boston Children’s Hospital have logged on for their weekly meeting. “We meet first thing every Monday to discuss our complex cases,” says orthopedic surgeon Dr. Carley Vuillermin. “It gives us a chance to talk through treatment options for our patients ... Read More
Bringing the Ozaki procedure to the world to repair children’s aortic valves
Children with aortic stenosis or regurgitation often need surgery to reconstruct or replace the aortic valve. However, existing bioprosthetics can fail over time, and mechanical leaflets and valves require lifelong anticoagulant therapy. Christopher Baird, MD, director of the Congenital Heart Valve Program at Boston Children’s Hospital, saw a promising alternative emerge in adult cardiac surgery: aortic ... Read More
I tried the keto diet to help my epilepsy and it changed my life
My name is Dennis. I’m 15 years old and live in East Greenwich, Rhode Island. Two years ago, I started the keto diet to help my epilepsy and it changed my life. Here’s my story… I was 7 when I was diagnosed with epilepsy. I was too young to know what that really meant or ... Read More
Generations of excellence in lower extremity care: Dr. Kasser and Dr. May
As an orthopedic surgeon and professor of surgery, Dr. James Kasser has spent several decades sharing his expertise in limb reconstruction with students of Harvard Medical School. Dr. Collin May was one of his students and later joined the surgical team in the Lower Extremity Program at Boston Children’s Hospital. He has spent the past ... Read More
Gait analysis gives runners a window into their form
Why can some runners compete in marathon after marathon while others get injured? The answer often lies in the runner’s form. According to Dr. Kristin Whitney, co-director of the Injured Runners Clinic at Boston Children’s Hospital, many runners aren’t aware of subtleties like how hard their feet hit the ground or the angle of their ... Read More
Limb-lengthening surgery: A look at the pros and cons
Limb length discrepancies, a leg or arm that’s shorter than the other, can occur for a number of reasons. A child may be born with a condition that causes one limb to grow more slowly than the other. An arm or leg may stop growing after a complex fracture or a fracture that heals incorrectly. ... Read More
Inspired by Chinese finger traps, an annuloplasty ring that grows with the child
This post is part of a series on innovations to treat valvular disease in children. Read our prior posts on transcatheter valve replacement and an expandable prosthetic heart valve. Prosthetic annuloplasty rings have improved the durability of heart valve repairs in adults. Implanted at the perimeter of dilated, leaky valves, they help keep the valve ... Read More
Children with severe MIS-C do better with IVIG and steroids as initial therapy
When children started getting sick with multisystem inflammatory syndrome (MIS-C) in the wake of COVID-19, clinicians largely turned to two treatments. Many used immunoglobulin (IVIG) because of MIS-C’s similarities with Kawasaki disease. And many used steroids such as methylprednisolone because of MIS-C’s inflammatory features. Key takeawayIn this large, rigorous national study, initial treatment of MIS-C ... Read More