Archive for leukemia
Nurses Week 2021: Integrating new therapies into nursing practice and patient care delivery
A revolution in pharmacological gene therapy is underway, as indicated by a significant acceleration in the creation of new therapies to treat genetic disorders at the molecular level. Boston Children’s Hospital Nursing and extended team members, in collaboration with hospital researchers and scientists, biotech, and biopharma partners, have developed a set of specific processes to ... Read More about Nurses Week 2021: Integrating new therapies into nursing practice and patient care delivery
Can we prevent leukemia in patients with Shwachman-Diamond syndrome?
Anna Nazarenko doesn’t see herself as sick. The strong-willed, spunky 6-year-old loves to dance and ski, and spent much of April Fool’s day pranking her parents. Aside from the enzymes she takes to help digest her food, you wouldn’t know that she has Shwachman-Diamond syndrome (SDS). The rare, inherited type of bone marrow failure has ... Read More about Can we prevent leukemia in patients with Shwachman-Diamond syndrome?
Arthritis drug reduces rates of acute graft-vs-host disease after bone marrow transplant
The immune-suppressing drug abatacept, currently used for rheumatoid arthritis, could make bone marrow transplant safer, report researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. The phase 2 randomized, multi-center clinical trial, the largest to date, appears in the Journal of Clinical Oncology. Abatacept (brand name ORENCIA) reduced rates of severe, acute graft-versus-host disease ... Read More about Arthritis drug reduces rates of acute graft-vs-host disease after bone marrow transplant
Cancer won’t stop me, and neither will COVID-19
Most people my age look at COVID-19 as a burden on their everyday lives of seeing friends, hanging out, and going to college. I see it differently. As an active cancer patient being treated for T-cell acute lymphoblastic leukemia (ALL), I am immunocompromised. This puts me at especially high risk for contracting COVID-19, and my ... Read More about Cancer won’t stop me, and neither will COVID-19
Could leukemia be stopped before it starts?
Acute myeloid leukemia (AML), a blood cancer affecting both adults and children, requires more than one genetic “hit” to develop. As we age, many of us acquire a mutation that enables certain of our blood cells to multiply faster than others, forming their own distinct population. This first hit, known as “clonal hematopoiesis of indeterminate ... Read More about Could leukemia be stopped before it starts?
Bone marrow-on-a-chip provides new research directions for Shwachman-Diamond syndrome
A new research tool that mimics the behavior of diseased bone marrow provides a new strategy for understanding the bone marrow disease, Shwachman-Diamond syndrome (SDS), and hopefully, developing new treatments. With SDS, bone marrow fails to produce blood cells normally, leading to bone marrow failure and an increased risk of leukemia. In a research paper ... Read More about Bone marrow-on-a-chip provides new research directions for Shwachman-Diamond syndrome
Targeted small-molecule agent shows early promise against a dangerous infant leukemia
Leukemias involving reshuffling or rearrangement of the mixed lineage leukemia (MLL) gene, known as MLL-rearranged or MLL-r leukemias, account for 70 to 80 percent of acute leukemias in infants under one year old. In these blood cancers, a subset of acute myeloid and acute lymphoid leukemias (AML and ALL), the MLL gene breaks and reattaches ... Read More about Targeted small-molecule agent shows early promise against a dangerous infant leukemia
A big step toward curbing graft-vs.-host disease after bone marrow transplant
A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use. The drug, abatacept, has gained FDA Breakthrough Therapy Designation for preventing acute, severe graft-versus-host disease (GVHD) in patients receiving bone marrow transplants. That could help fast-track the drug to the clinic. “If we are lucky ... Read More about A big step toward curbing graft-vs.-host disease after bone marrow transplant
Teen author dedicates a children’s book to her twin brother with Shwachman-Diamond syndrome
Sophia Namazy, 14, has a hero: it’s her twin brother Max, who has Shwachman-Diamond syndrome. This is a rare and very serious genetic condition that impacts multiple systems in the body, including the bone marrow, pancreas, skeleton, and immune system. Although her brother is currently doing well, people with this disease have a high risk ... Read More about Teen author dedicates a children’s book to her twin brother with Shwachman-Diamond syndrome
How families are reshaping Shwachman-Diamond syndrome research
No one knew the heartache about to unfold when Savannah and Brett Lillywhite first began thinking about having a family 10 years ago. The Lillywhites Savannah and Brett are both the unlikely carriers of a rare condition called Shwachman-Diamond syndrome — SDS for short — a blood disorder that can lead to bone marrow failure ... Read More about How families are reshaping Shwachman-Diamond syndrome research