Obesity is increasing people’s risk of cancer. Why?
Obesity is now a global epidemic, and it is increasing people’s risk for cancer. The National Cancer Institute lists more than a dozen cancers that are associated with overweight and obesity. But how obesity increases cancer risk hasn’t been clear. The lab of Marsha A. Moses, PhD, at Boston Children’s Hospital, now draws a direct ... Read More about Obesity is increasing people’s risk of cancer. Why?
Genetic sequencing may open doors for newborns with hypotonia
When a baby is born with low muscle tone (hypotonia), the future is hard to predict, and families have a lot of questions. How should neonatologists care for these infants? Findings from a recent review could help provide some answers, guide appropriate interventions, and in some cases open the way to custom treatments. Diagnosing a ... Read More about Genetic sequencing may open doors for newborns with hypotonia
New insight into dietary approaches for epilepsy
Fasting has been believed since ancient times to curb seizures in epilepsy, and small patient studies in the early 1900s have revived the idea. But the reasons have remained mysterious. New research from Boston Children’s helps explain how fasting affects the brain at the molecular level. The findings could lead the way to new approaches ... Read More about New insight into dietary approaches for epilepsy
Preventing ‘chemo brain’ with antioxidants targeting the spinal fluid
Up to three-quarters of patients receiving cancer chemotherapy suffer from “chemo brain” — a side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, effects are sometimes long lasting, affecting their schoolwork and self-esteem. “One of the most distressing potential side ... Read More about Preventing ‘chemo brain’ with antioxidants targeting the spinal fluid
A new view of heart health: Mutations accumulate in the heart starting in childhood
Why do so many people get heart disease when they get older? We know that factors like high blood pressure or high cholesterol contribute to heart disease risk, but they don’t explain all cases. A first-of-its-kind study from Boston Children’s Hospital offers a new lens on heart health. It shows that the cells of our ... Read More about A new view of heart health: Mutations accumulate in the heart starting in childhood
How protected am I from COVID-19? A new test could tell you at home
Say you’re going to a wedding or a concert or are about to leave the country. You’ve been vaccinated against COVID-19, even boosted, but you have an underlying medical condition. You might have a young child who’s received only one vaccine dose. How much protection do you and your family have? Do you need another ... Read More about How protected am I from COVID-19? A new test could tell you at home
Powerful new antibody neutralizes all known coronavirus variants
As the COVID-19 pandemic wears on, newer variants of the SARS-CoV-2 coronavirus have been evolving ways to evade the antibodies we make in response to vaccines or prior infections. As a result, we’ve seen breakthrough cases, antibody treatments that once worked have also become less effective over time. Scientists have been searching for an antibody ... Read More about Powerful new antibody neutralizes all known coronavirus variants
Weight loss: When scientific paradigms collide
David S. Ludwig, MD, PhD, co-directs the New Balance Foundation Obesity Prevention Center at Boston Children’s Hospital. Because conventional thinking usually rests on years (sometimes centuries) of research, scientists are naturally skeptical of radical new ideas. But occasionally, problems with normal science arise, such as a persistent failure to solve important puzzles and anomalies that can’t be ... Read More about Weight loss: When scientific paradigms collide
Making ready-made CAR T cells for cancer immunotherapy
In CAR T-cell immunotherapy, T cells from a patient’s own blood are engineered to carry so-called chimeric antigen receptors (CAR) that enable the T cells to attack and kill tumor cells. While CAR-T therapy is a powerful approach for certain leukemias and lymphomas, it’s not available for many patients who need it. It can be ... Read More about Making ready-made CAR T cells for cancer immunotherapy
A new vaccine formulation could finally protect babies against RSV
Though often mild, respiratory syncytial virus (RSV) infection can cause babies to be hospitalized with bronchiolitis or pneumonia. Globally, it is the leading cause of death in children under 5. Several vaccines against RSV are being tested in adults. But there has been no progress on an RSV vaccine for children since 1966 — the ... Read More about A new vaccine formulation could finally protect babies against RSV