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Model enables study of age-specific responses to COVID mRNA vaccines in a dish

Posted on by | Clinical, Research
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mRNA vaccines clearly saved lives during the COVID-19 pandemic, but several studies suggest that older people had a somewhat reduced immune response to the vaccines when compared with younger adults. Why? Researchers at Boston Children’s Hospital, led by Byron Brook, PhD, David Dowling, PhD, and Ofer Levy, MD, PhD, found some answers — while providing ... Read More
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Could a pill treat sickle cell disease?

Posted on by | Basic/Translational, Research
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The new gene therapies for sickle cell disease — including the gene-editing treatment Casgevy, based on research at Boston Children’s Hospital — have been game-changing for the patients who have received them. But Stuart Orkin, MD, the Boston Children’s hematologist whose work led the way to Casgevy, wants to go even further. “The editing therapy ... Read More
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A sickle cell first: Base editing, a new form of gene therapy, leaves Branden feeling ‘more than fine’

Posted on by | Clinical, Research
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Though he doesn’t remember it, Branden Baptiste had his first sickle cell crisis at age 2. Through elementary school, he was in and out of the hospital with pain episodes, not knowing why. As he got older, he learned he had sickle cell disease. His red blood cells were forming sickle shapes and getting stuck ... Read More
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Keeping up with the tween skin care trend: What’s in those products?

Posted on by | Health and Parenting
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More teens and tweens are hitting the mall to grab skin-care products they’ve seen on social media — but are these popular ingredients safe for younger skin? We asked Dr. Jennifer Tan and Dr. Jennifer Huang in Boston Children’s Dermatology Program to weigh in on this trend and break down common ingredients. Trends aren’t for ... Read More
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Then and now: Catching up with some of our short bowel syndrome kids

Posted on by | Patient Stories
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Also known as “short gut,” short bowel syndrome is a life-threatening condition in which a lack of functioning intestine can make it difficult to absorb the nutrients needed to survive and thrive. Thanks to advances in medical and surgical treatments — many of which have been made by the team in Boston Children’s Center for Advanced ... Read More
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Injected microbubbles could be a safe way to deliver emergency oxygen

Posted on by | Basic/Translational, Research
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For years, researchers and clinicians have been trying to find a way to rapidly deliver oxygen to patients when traditional means of oxygenation are difficult or ineffective during critical moments of cardiac or respiratory arrest. Sometimes, hypoxemia caused by airway obstruction or lung disease can be so severe that methods to boost low-oxygen levels (including ... Read More
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A universal gene therapy for Diamond-Blackfan anemia is poised for clinical testing

Posted on by | Basic/Translational, Research
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Diamond-Blackfan anemia (DBA), first described at Boston Children’s Hospital in 1938, is a rare blood disorder in which the bone marrow cannot make mature, functioning red blood cells. Children with this life-threatening anemia have few treatment options. A small handful with a well-matched donor can be cured with bone marrow transplant, but most rely on ... Read More
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A heavy-medaled gymnast and his close call with leg-length discrepancy

Posted on by | Patient Stories
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Ask 15-year-old Kaleb what he likes about gymnastics and with a sly smile, he’ll say, “flipping around.” That’s Kaleb: understated, funny. But watch him in action, and you’ll see a focused gymnast who earned two medals in the 2024 Men’s Eastern National Championships. He probably won’t mention that two years ago, a surgeon told his ... Read More
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Skin organoid could guide new treatments for skin conditions, hair loss

Posted on by | Basic/Translational, Research
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What does it take to build healthy skin? Two research groups converged on this question from different angles. They’ve now produced the most detailed view to date of the cell types and cell collaborations that go into creating our body’s largest organ. Several years ago, Karl Koehler, PhD, and colleagues at Boston Children’s Hospital used ... Read More
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Fuel to be faster: Studying the effects of low energy availability at the Boston Marathon

Posted on by | Clinical, Research
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Like many sports medicine specialists, Kristin Whitney, MD, MA, suspected that many of the issues she treats in runners — bone stress injuries, anemia, decreased response to training, and reduced endurance to name a few — stemmed from insufficient nutrition. Key takeaways Runners with indicators of low energy availability had slower finish times and more ... Read More
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