Search Results for: PCMM
Diversifying therapeutic antibodies: From one, come many with potential different uses
A new method for producing antibodies against disease could result in a wider variety of drugs for infectious diseases, immune …Read More
Specialized T cells protect against the deadliest form of malaria
Each year, there are about 230 million cases of malaria globally. Children under the age of 5 are at highest …Read More
Chromatin regulation enables generation of diverse antibodies
We need a variety of antibody types to help fight off invading foreign pathogens and our genome is exquisitely tuned …Read More
A COVID-19 DNA nanoswitch: A new kind of test for a new kind of virus
When the COVID-19 pandemic shut down research laboratories across the country, several labs at Boston Children’s Hospital geared up, including …Read More
Natural killer cells: Protect the placenta cell but kill the infection
Infections that reach the placenta can lead to spontaneous abortions, intrauterine growth restriction, congenital abnormalities, and premature births. New research …Read More
Antibodies in the gut: Roles in autoimmune disease, food allergy… and COVID-19?
From our tonsils through our intestines, the lining of our gastrointestinal tract forms a border between our body and the …Read More
Disulfiram inhibits inflammatory gatekeeper protein: Could it be helpful in COVID-19?
Inflammation is the alarm system by which cells first respond to potential danger. But in excess, inflammation can be deadly. …Read More
Gasdermin E: A new approach to cancer immunotherapy
Tumors have figured out various ways to prevent the immune system from attacking them. Medicine, for its part, has fought …Read More
Boosting host immune defenses to treat tuberculosis
Current treatment regimens for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, are long, complex, and hard for people to …Read More
Unlocking antibody diversity: chromatin loops, V(D)J recombination, and class switching
A new study from the laboratory of Frederick Alt, PhD, of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children’s …Read More