Search Results for: PCMM
Gasdermin E: A new approach to cancer immunotherapy
Tumors have figured out various ways to prevent the immune system from attacking them. Medicine, for its part, has fought …Read More
Boosting host immune defenses to treat tuberculosis
Current treatment regimens for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, are long, complex, and hard for people to …Read More
Unlocking antibody diversity: chromatin loops, V(D)J recombination, and class switching
A new study from the laboratory of Frederick Alt, PhD, of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children’s …Read More
Targeting a rogue T cell prevents and reverses multiple sclerosis in mice
Multiple sclerosis is an autoimmune disease affecting both adults and children. It’s driven by “helper” T cells, white blood cells …Read More
How new loops in DNA packaging help us make diverse antibodies
Diversity is good, especially when it comes to antibodies. It’s long been known that a gene assembly process called V(D)J …Read More
PET imaging shows if PD-1 cancer immunotherapy is working
PD-1 is a protein on our T cells that normally keeps these immune cells from running amok. A growing number …Read More
‘Nanobodies’ from alpacas could help bring CAR T-cell therapy to solid tumors
In 1989, two undergraduate students at the Free University of Brussels were asked to test frozen blood serum from camels, …Read More
Blood stem cell transplants from any donor, without toxicity?
Many blood disorders, immune disorders and metabolic disorders can be cured with a transplant of hematopoietic (blood-forming) stem cells, also …Read More
Creating custom brains from the ground up
Scientists studying how genetics impact brain disease have long sought a better experimental model. Cultures of genetically-modified cell lines can …Read More
“Teenage” red blood cells could hold the key to a malaria vaccine
Malaria parasite infection, which affects our red blood cells, can be fatal. Currently, there are about 200 million malaria infections …Read More