Archive for immunology
Tim Springer: Scientist, entrepreneur, and mentor
As an undergraduate in 1966, immunologist, biochemist, and biophysicist Timothy A. Springer, PhD, looked askance at science. The Vietnam War was going on, and he saw science as a means of making Agent Orange and napalm. Questioning his own Ivy League education, he left Yale to spend a year as a VISTA volunteer on a ... Read More about Tim Springer: Scientist, entrepreneur, and mentor
Beyond COVID-19: Why kids need other vaccines, too
As you consider immunizing your child, it’s natural to have questions about the safety and effectiveness of vaccines. But the detection of polio in New York illustrates how diseases that were once thought to have been eradicated can reemerge when vaccination efforts lag. While COVID-19 vaccines have understandably drawn attention during recent years, it’s important to remember ... Read More about Beyond COVID-19: Why kids need other vaccines, too
Powerful new antibody neutralizes all known coronavirus variants
As the COVID-19 pandemic wears on, newer variants of the SARS-CoV-2 coronavirus have been evolving ways to evade the antibodies we make in response to vaccines or prior infections. As a result, we’ve seen breakthrough cases, antibody treatments that once worked have also become less effective over time. Scientists have been searching for an antibody ... Read More about Powerful new antibody neutralizes all known coronavirus variants
A new vaccine formulation could finally protect babies against RSV
Though often mild, respiratory syncytial virus (RSV) infection can cause babies to be hospitalized with bronchiolitis or pneumonia. Globally, it is the leading cause of death in children under 5. Several vaccines against RSV are being tested in adults. But there has been no progress on an RSV vaccine for children since 1966 — the ... Read More about A new vaccine formulation could finally protect babies against RSV
Previous COVID-19 or MIS-C does not protect kids from Omicron
You would think that having had COVID-19 once, you’d have antibodies that would protect you against repeat infections. But studies of adults have shown that Omicron doesn’t go by that logic. A new study, led by Dr. Adrienne Randolph of Boston Children’s Hospital and Dr. Surender Khurana of the Food and Drug Administration, confirms that ... Read More about Previous COVID-19 or MIS-C does not protect kids from Omicron
Old vaccine, new tricks? Unlocking the BCG vaccine’s potential
Could a century-old vaccine offer clues for designing the vaccines of tomorrow? Ofer Levy, MD, PhD, director of the Precision Vaccines Program at Boston Children’s Hospital, wants to find out. One of the world’s oldest and most widely used vaccines, the Bacille Calmette-Guérin (BCG) tuberculosis vaccine may at first seem like an unlikely source of ... Read More about Old vaccine, new tricks? Unlocking the BCG vaccine’s potential
How COVID-19 triggers massive inflammation
Why do some people with COVID-19 develop severe inflammation, leading to respiratory distress and damage to multiple organs? A new study in the journal Nature provides an explanation: the SARS-CoV-2 virus infects and kills critical immune cells in the blood and lungs, which set off powerful alarm bells as they die. Judy Lieberman, MD, PhD, ... Read More about How COVID-19 triggers massive inflammation
From our labs and clinics: The top 10 COVID-19 science stories of 2021
As COVID-19 waxed, waned, morphed, and waxed again this year, research was taking place throughout Boston Children’s Hospital. Ongoing national studies the hospital is leading or co-leading include Overcoming COVID-19, a CDC-funded study on COVID-19 and multisystem inflammatory syndrome in children (MIS-C); IMPACC, examining immune responses in people hospitalized with COVID-19; and MUSIC, studying MISC’s ... Read More about From our labs and clinics: The top 10 COVID-19 science stories of 2021
New research NETs a fresh angle for treating severe inflammation
As we’ve seen during the COVID-19 pandemic, serious infections sometimes trigger an excessive inflammatory reaction that does as much harm — or more — than the infection itself. New research at Boston Children’s Hospital and Brigham and Women’s Hospital suggests a potential way to block this hyperinflammation response by repurposing or modifying an existing drug. ... Read More about New research NETs a fresh angle for treating severe inflammation
Unpacking the body’s interferon response to COVID-19
Interferons are potent natural antivirals, rallying other parts of the immune system to defend against viruses. Some clinical trials have tested interferons as a treatment for COVID-19, but results have been mixed. And the science has been unclear about whether interferons are helpful or harmful. Key takeawayAn early, protective interferon response in the upper respiratory ... Read More about Unpacking the body’s interferon response to COVID-19