Archive for global health
100 years after the advent of TB vaccines, formulations vary widely
Each year, more than 100 million newborns around the world receive vaccinations against Mycobacterium tuberculosis, or TB, which infects about one-quarter of the world’s population. Facilities across the world produce several different formulations of these vaccines, known as Bacille Calmette-Guérin (BCG) vaccines. These are given interchangeably, yet new research from the Precision Vaccines Program at ... Read More about 100 years after the advent of TB vaccines, formulations vary widely
Boosting host immune defenses to treat tuberculosis
Current treatment regimens for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, are long, complex, and hard for people to sustain. Moreover, the bacteria often develop drug resistance, and many people harbor multi-drug-resistant strains. In 2018 alone, nearly 1.5 million people died from tuberculosis worldwide. Now, a study in iScience suggests a new approach that ... Read More about Boosting host immune defenses to treat tuberculosis
Existing anti-parasitic drug could offer a treatment for Ebola
Amid the worsening Ebola outbreak in the Congo, now threatening to spill into Rwanda, a new study suggests that an existing, FDA-approved drug called nitazoxanide could potentially help contain this deadly, highly contagious infection. In meticulous experiments in human cells, described today in iScience, the drug significantly amplified immune responses to the virus and inhibited ... Read More about Existing anti-parasitic drug could offer a treatment for Ebola
My nursing story: Alexis Schmid
Dr. Alexis Schmid is a nurse in the Emergency Department at Boston Children’s Hospital and the Maggie Ryan Endowed Global Health Fellow. Fifty million children around the world are currently migrants or refugees, uprooted from their homes due to violence, poverty, or other factors out of their control. The statistics are alarming: Approximately 70 percent ... Read More about My nursing story: Alexis Schmid
The threat from mosquito-borne diseases: Forecasting mosquitoes’ global spread
Outbreaks of mosquito-borne illnesses like yellow fever, dengue, Zika and chikungunya are rising around the world. Climate change has created conditions favorable to mosquitoes’ spread, but so have human travel and migration and accelerating urbanization, creating new mini-habitats for mosquitoes. In Nature Microbiology yesterday, a large group of international collaborators combined these factors into prediction models that ... Read More about The threat from mosquito-borne diseases: Forecasting mosquitoes’ global spread
“Teenage” red blood cells could hold the key to a malaria vaccine
Malaria parasite infection, which affects our red blood cells, can be fatal. Currently, there are about 200 million malaria infections in the world each year and more than 400,000 people, mostly children, die of malaria each year. Now, studying blood samples from patients treated for malaria at a clinical field station in Brazil’s Amazon jungle, ... Read More about “Teenage” red blood cells could hold the key to a malaria vaccine
Effective vaccination of newborns: Getting closer to the dream
In many parts of the world, babies have just one chance to be vaccinated: when they’re born. Unfortunately, newborns’ young immune systems don’t respond well to most vaccines. That’s why, in the U.S., most immunizations start at two months of age. Currently, only BCG, polio vaccine and hepatitis B vaccines work in newborns, and the ... Read More about Effective vaccination of newborns: Getting closer to the dream